“…Despite being discovered in 1822 by Charles Cagniard de La Tour and being used for the rst time as extraction solvents in 1879 by Hannay and Hogarth, SCFs were not given much consideration until the late 1950s, when numerous papers suggested their use as eluents for chromatography in a plethora of applications. [30][31][32] In a few years, the interesting properties of SCFs were studied in depth; in particular, they were (and still are) studied for their remarkable extractive properties, which, nowadays, are applied in a lot of elds, such as food industry [33][34][35][36][37][38] (e.g., decaffeination of coffee, extraction of essential oils from spices), petrochemical industry [39][40][41] (e.g., fractionation of oil) and pharmaceutical industry [42][43][44] (e.g., enantiomeric separation, extraction of drugs from plants, milling). Today, SFE is a relevant industrial technology spanning from the extraction of solids and liquids to polymer processing, supercritical drying and cleaning, and chemical and biochemical reactions.…”