Fluid-structure analysis of microparticle transport in deformable pulmonary alveoli

Dailey, Hannah L.; Ghadiali, Samir N.

doi:10.1016/j.jaerosci.2007.01.001

Cited by 49 publications

(46 citation statements)

References 28 publications

(43 reference statements)

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“…following equation for sub-ambient pressure (vacuum), which was reported by Dailey and Ghadiali [9]:…”

Section: Model Development and Fsi Approachmentioning

confidence: 98%

“…The visco-elastic model draws on the Kelvin-Voigt visco-elastic model shown in Figure 2. following equation for sub-ambient pressure (vacuum), which was reported by Dailey and Ghadiali [9]:…”

Section: Fluid-structure Interaction Equationsmentioning

confidence: 98%

“…This load expands the alveoli and establishes a sub-ambient pressure (vacuum) within the lungs. Only a few studies have employed visco-elastic walls and calculated tissue stresses, but these studies were performed only for two-dimensional models [9]. Moreover, as it is important to choose suitable physiological parameter values such as magnitude of the pressure in the modelling, we utilize the following equation for sub-ambient pressure (vacuum), which was reported by Dailey and Ghadiali [9]:…”

Section: Model Development and Fsi Approachmentioning

confidence: 99%

“…For example, Henry et al applied sinusoidal oscillations for a fully-alveolated alveolar duct [8], but they neglected Brownian diffusion forces. However, some studies have accounted for the Brownian force and compared the root mean square (RMS) displacement of a Brownian particle to the theoretical diffusion predicted by Einstein theory for validating a particle motion algorithm [9]. The gravitational deposition of particles in rhythmically expanding and contracting alveolar models has been analysed and it was shown that wall motion is a cardinal factor in particle transport [10].…”

Section: Introductionmentioning

confidence: 99%

“…The gravitational deposition of particles in rhythmically expanding and contracting alveolar models has been analysed and it was shown that wall motion is a cardinal factor in particle transport [10]. In this regard, fluid structure interaction models can be developed for more accurate results and to investigate how breathing pattern models and lung tissue mechanical properties affect deep-lung flow fields and particle dynamical transport [9].…”

Section: Introductionmentioning

confidence: 99%

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Importance of Physical and Physiological Parameters in Simulated Particle Transport in the Alveolar Zone of the Human Lung

Çiloğlu

Athari²,

Bölükbaşi

et al. 2017

Applied Sciences

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Abstract:The trajectory and deposition efficiency of micron-sized (1-5 µm) particles, inhaled into the pulmonary system, are accurately determined with the aid of a newly developed model and modified simulation techniques. This alveolar model, which has a simple but physiologically appropriate geometry, and the utilized fluid structure interaction (FSI) methods permit the precise simulation of tissue wall deformation and particle fluid interactions. The relation between tissue movement and airflow in the alveolated duct is solved by a two-way fluid structure interaction simulation technique, using ANSYS Workbench (Release 16.0, ANSYS INC., Pittsburgh, PA, USA, 2015). The dynamic transport of particles and their deposition are investigated as a function of aerodynamic particle size, tissue visco-elasticity, tidal breathing period, gravity orientation and particle-fluid interactions. It is found that the fluid flows and streamlines differ between the present flexible model and rigid models, and the two-way coupling particle trajectories vary relative to one-way particle coupling. In addition, the results indicate that modelling the two-way coupling particle system is important because the two-way discrete phase method (DPM) approach despite its complexity provides more extensive particle interactions and is more reliable than transport results from the one-way DPM approach. The substantial difference between the results of the two approaches is likely due to particle-fluid interactions, which re-suspend the sediment particles in the airway stream and hence pass from the current generation.

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“…following equation for sub-ambient pressure (vacuum), which was reported by Dailey and Ghadiali [9]:…”

Section: Model Development and Fsi Approachmentioning

confidence: 98%

Section: Fluid-structure Interaction Equationsmentioning

confidence: 98%

Section: Model Development and Fsi Approachmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Importance of Physical and Physiological Parameters in Simulated Particle Transport in the Alveolar Zone of the Human Lung

Çiloğlu

Athari²,

Bölükbaşi

et al. 2017

Applied Sciences

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Particle Transport and Deposition: Basic Physics of Particle Kinetics

Tsuda

Henry

Butler

2013

Comprehensive Physiology

213

162

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The human body interacts with the environment in many different ways. The lungs interact with the external environment through breathing. The enormously large surface area of the lung with its extremely thin air-blood barrier is exposed to particles suspended in the inhaled air. Whereas the particle-lung interaction may cause deleterious effects on health if the inhaled pollutant aerosols are toxic, this interaction can be beneficial for disease treatment if the inhaled particles are therapeutic aerosolized drug. In either case, an accurate estimation of dose and sites of deposition in the respiratory tract is fundamental to understanding subsequent biological response, and the basic physics of particle motion and engineering knowledge needed to understand these subjects is the topic of this chapter. A large portion of this chapter deals with three fundamental areas necessary to the understanding of particle transport and deposition in the respiratory tract. These are: 1) the physical characteristics of particles, 2) particle behavior in gas flow, and 3) gas flow patterns in the respiratory tract. Other areas, such as particle transport in the developing lung and in the diseased lung are also considered. The chapter concludes with a summary and a brief discussion of areas of future research.

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A preliminary study of dynamic interactive simulation and computational CT scan of the ideal alveolus model

Liu,

Li,

Huang

et al. 2023

Medical Physics

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BackgroundWhile the development of CT imaging technique has brought cognition of in vivo organs, the resolution of CT images and their static characteristics have gradually become barriers of microscopic tissue research.PurposePrevious research used the finite element method to study the airflow and gas exchange in the alveolus and acinar to show the fate of inhaled aerosols and studied the diffusive, convective, and sedimentation mechanisms. Our study combines these techniques with CT scan simulation to study the mechanisms of respiratory movement and its imaging appearance.MethodsWe use 3D fluid‐structure interaction simulation to study the movement of an ideal alveolus under regular and forced breathing situations and ill alveoli with different tissue elasticities. Additionally, we use the Monte Carlo algorithm within the OpenGATE platform to simulate the computational CT images of the dynamic process with different designated resolutions. The resolutions show the relationship between the kinematic model of the human alveolus and its imaging appearance.ResultsThe results show that the alveolus and the wall thickness can be seen with an image resolution smaller than 15.6 μm. With ordinary CT resolution, the alveolus is expressed with four voxels.ConclusionsThis is a preliminary study concerning the imaging appearance of the dynamic alveolus model. This technique will be used to study the imaging appearance of the dynamic bronchial tree and the lung lobe models in the future.

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Fluid-structure analysis of microparticle transport in deformable pulmonary alveoli

Cited by 49 publications

References 28 publications

Importance of Physical and Physiological Parameters in Simulated Particle Transport in the Alveolar Zone of the Human Lung

Importance of Physical and Physiological Parameters in Simulated Particle Transport in the Alveolar Zone of the Human Lung

Particle Transport and Deposition: Basic Physics of Particle Kinetics

A preliminary study of dynamic interactive simulation and computational CT scan of the ideal alveolus model

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