Fluid shifts have no influence on ciprofloxacin pharmacokinetics in intensive care patients with intra-abdominal sepsis

Importance of Relating Efficacy Measures to Unbound Drug Concentrations for Anti-Infective Agents

“…The time course of changes in the PK of these drugs therefore mirrors that of the patient's pathophysiology (131), a phenomenon observed for vancomycin (132,133), amikacin (134), and beta-lactams (135), to name a few. On the other hand, for drugs that distribute into extra-and intracellular spaces, such as quinolones (136), moderate changes in the volume of distribution as a result of disease are less important and are likely to require no adjustment of the loading dose.…”

Ciprofloxacin use in critically ill patients: pharmacokinetic and pharmacodynamic approaches

“…If at least two elimination pathways are observed in a disease state, a deterioration of ciprofloxacin elimination could be highlighted [34]. Gous et al [35] showed that intra-abdominal infections did not have any influence on ciprofloxacin pharmacokinetic parameters in 40 critically ill patients. In the case of impaired renal function (CL Cr < 30 mL/min), Shah et al [36] showed that if ciprofloxacin accumulates there can be side effects, but there were few patients in this category (n = 10).…”

Application of single drop liquid–liquid–liquid microextraction for the determination of fluoroquinolones in human urine by capillary electrophoresis

“…Results are shown in Table 2. It exhibited good correlation coefficients (0.9913-0.9995) for the concentration range of 40-1000 g L −1 [30][31][32][33][34]. The LOD varied from 7.4 to 31.5 g L −1 at a signal-to-noise (S/N) of 3.…”