Fluid Resuscitation in Traumatic Hemorrhagic Shock

Falk, Jay L.; O’Brien, John F.; Kerr, Robert B.

doi:10.1016/s0749-0704(18)30253-7

Cited by 54 publications

(24 citation statements)

References 86 publications

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“…The mortality of hypovolemic shock is directly related to the severity and duration of organ hypoperfusion; prompt volume replacement is the hallmark of success in managing the hypovolemic patient [1]. However, since fluid resuscitation requires some time to accomplish, maneuvers such as the Trendelenburg position or passive leg raising (PLR) are commonly used as the initial treatment of shock and hypotension [2].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive review: is it better to use the Trendelenburg position or passive leg raising for the initial treatment of hypovolemia?

Geerts¹,

Bergh²,

Stijnen³

et al. 2012

Journal of Clinical Anesthesia

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Section: Introductionmentioning

confidence: 99%

Comprehensive review: is it better to use the Trendelenburg position or passive leg raising for the initial treatment of hypovolemia?

Geerts¹,

Bergh²,

Stijnen³

et al. 2012

Journal of Clinical Anesthesia

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“…Current fluid resuscitation methods include the administration of colloid or crystalloid solutions (Falk et al ., 1992), followed by the transfusion of oxygen-carrying blood. These resuscitation methods are aimed at restoring circulating blood volume, even at the cost of a lower-than-normal hematocrit or hemoglobin concentration (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Hemorrhagic shock and nitric oxide release from erythrocytic nitric oxide synthase: A quantitative analysis

Chen

Pittman

Popel

2009

Microvascular Research

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A large loss of blood during hemorrhage can result in profound shock, a state of hypotension associated with hemodynamic abnormalities. One of the hypotheses to account for this collapse of homeostasis is that the production of nitric oxide (NO), a gas molecule that dilates blood vessels, is significantly impaired during hemorrhage, resulting in a mismatch between O 2 delivery and the metabolic activity in the tissues. NO can be released from multiple sources in the vasculature. Recent studies have shown that erythrocytes express functional endothelial nitric oxide synthase (NOS3), which potentially serves as an intraluminal NO source. NO delivery from this source is complex: Erythrocytes are not only NO producers but also act as potent sinks because of the high affinity of NO for hemoglobin. To test our hypothesis that the loss of erythrocytic NOS3 during hemorrhage contributes to NO deficiency-related shock, we have constructed a multicellular computational model that simulates NO production and transport to allow us to quantify the loss of NO under different hemorrhagic conditions. Our model shows that: (1) during mild hemorrhage and subsequent hemodilution (hematocrit >30%), NO from this intraluminal source is only slightly decreased in the vascular smooth muscle, but the NO level is significantly reduced under severe hemorrhagic conditions (hematocrit <30%); (2) whether a significant amount of NO from this source can be delivered to vascular smooth muscle is strongly dependent on the existence of a protective mechanism for NO delivery; (3) if the expression level of NOS3 on erythrocytes is similar to that on endothelial cells, we estimate ~13 pM NO at the vascular smooth muscle from this source when such a protective mechanism is involved. This study provides a basis for detailed studies to characterize the impairment of NO release pathways during hemorrhage and yield important insights for the development of resuscitation methods.

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“…[14] IBS has been used in both anticipated and unanticipated massive haemorrhages like ectopic pregnancies, [15] caesarean sections, in vaginal deliveries and is acceptable under certain circumstances to Jehovah's witnesses. [16] The risk of IBS is embolism and alloimmunisation. To reduce this risk cell salvage is usually started after the majority of the amniotic fluid has been suctioned.…”

Section: Discussionmentioning

confidence: 99%

Blood Transfusion in Obstetric Haemorrhage and Their Outcome in Tertiary Care Hospital in Rural Area

Ganapathy¹,

Shunmugavelu²

2017

jemds

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BACKGROUNDObstetric haemorrhage remains the main cause of maternal mortality and morbidity, even though advanced medical and surgical managements and blood transfusions are available. Haemorrhagic shock is a very serious complication. Obstetric haemorrhage occur either in antepartum, intrapartum or postpartum period. Here, our aim is to study the outcome of blood transfusion in obstetric haemorrhage patients. Study Method-Retrospective observational study.

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Fluid Resuscitation in Traumatic Hemorrhagic Shock

Cited by 54 publications

References 86 publications

Comprehensive review: is it better to use the Trendelenburg position or passive leg raising for the initial treatment of hypovolemia?

Comprehensive review: is it better to use the Trendelenburg position or passive leg raising for the initial treatment of hypovolemia?

Hemorrhagic shock and nitric oxide release from erythrocytic nitric oxide synthase: A quantitative analysis

Blood Transfusion in Obstetric Haemorrhage and Their Outcome in Tertiary Care Hospital in Rural Area

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