2017
DOI: 10.1111/acem.13333 View full text |Buy / Rent full text
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Abstract: Hyperosmotic fluid resuscitation appears to be an attractive choice for severe burns in terms of TBSA or burn depth. Further investigation is recommended before conclusive recommendation.

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“…The other studies favored the use of HES 130 and revealed that this has a benefit over other therapies in terms of a mortality 15,16 benefit. According to a meta-analysis done by Kao et al, where they included 502 participants of burns and in this analysis they divided into two groups where they compared the iso-osmotic fluid resuscitation group, with the hyper-osmotic group and in the end they observed a significant decrease in the fluid load (vol/% total body surface area [TBSA ]/weight) at 24 hours post-injury, with a mean difference of −0.54 (95% confidence interval = −0.92 to −0.17).…”
Section: Resultsmentioning
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“…The other studies favored the use of HES 130 and revealed that this has a benefit over other therapies in terms of a mortality 15,16 benefit. According to a meta-analysis done by Kao et al, where they included 502 participants of burns and in this analysis they divided into two groups where they compared the iso-osmotic fluid resuscitation group, with the hyper-osmotic group and in the end they observed a significant decrease in the fluid load (vol/% total body surface area [TBSA ]/weight) at 24 hours post-injury, with a mean difference of −0.54 (95% confidence interval = −0.92 to −0.17).…”
Section: Resultsmentioning
“…On the other hand, there is evidence confirming the effectiveness of the other formulas used in fluid resuscitation, in particular in severe burns. Kao et al point out the positive effects of the use of hyperosmotic agents for this purpose, while Fodor et al describe the effective treatment examples based on a combination of crystalloids and plasma supply, provided that the initial fluid resuscitation is based on crystalloids [4,15].…”
Section: Discussionmentioning
“…Several recent studies have suggested that colloid is useful in decreasing total fluid administration, thereby reducing the risk of "fluid creep," edema formation, and compartment syndrome, especially when started on an as-needed basis later during the first postburn day. But there is little consensus with respect to indications or dosing, and use of colloid has not been demonstrated to have a mortality benefit [8,55,70,[80][81][82]. The approach to colloid rescue currently utilized at the US Army Burn Center is offered in Figure 4.…”
Section: Adjuncts To Resuscitationmentioning