Fluid homeostasis in chronic obstructive lung disease

Leeuw, Peter W. de; Dees, A

doi:10.1183/09031936.03.00000603a

Cited by 60 publications

(52 citation statements)

References 47 publications

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“…AVP decisively controls fluid homeostasis in COPD [54]. AVP seems to be inappropriately stimulated due to a reduction in effective circulating volume, but also due to non-osmotic stimuli, leading to a continuous expansion of extracellular volume and associated oedema formation in COPD [54]. AVP levels are also elevated in proportion to severity of heart failure and are associated with higher cardiovascular mortality in ambulatory patients [55].…”

Section: Discussionmentioning

confidence: 99%

“…ADM predicts death and rehospitalisation in patients with exacerbated COPD, refines the BODE index (''BODE-A'' index) and replaces the more cumbersome 6MWD (''BOD-A'' index) without sacrificing the predictive properties of the original composite score [9]. AVP decisively controls fluid homeostasis in COPD [54]. AVP seems to be inappropriately stimulated due to a reduction in effective circulating volume, but also due to non-osmotic stimuli, leading to a continuous expansion of extracellular volume and associated oedema formation in COPD [54].…”

Section: Discussionmentioning

confidence: 99%

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Mortality risk prediction in COPD by a prognostic biomarker panel

Stolz¹,

Meyer²,

Rakic³

et al. 2014

Eur Respir J

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Chronic obstructive pulmonary disease (COPD) is a complex disease with various phenotypes. The simultaneous determination of multiple biomarkers reflecting different pathobiological pathways could be useful in identifying individuals with an increased risk of death.We derived and validated a combination of three biomarkers (adrenomedullin, arginine vasopressin and atrial natriuretic peptide), assessed in plasma samples of 385 patients, to estimate mortality risk in stable COPD. Biomarkers were analysed in combination and defined as high or low.In the derivation cohort (n5142), there were 73 deaths during the 5-year follow-up. Crude hazard ratios for mortality were 3.0 (95% CI 1.8-5.1) for one high biomarker, 4.8 (95% CI 2.4-9.5) for two biomarkers and 9.6 (95% CI 3.3-28.3) for three high biomarkers compared with no elevated biomarkers. In the validation cohort (n5243), 87 individuals died. Corresponding hazard ratios were 1.9 (95% CI 1.1-3.3), 3.1 (95% CI 1.8-5.4) and 5.4 (95% CI 2.5-11.4). Multivariable adjustment for clinical variables as well as the BODE (body mass index, airflow obstruction, dyspnoea, exercise capacity) index and stratification by the Global Initiative for Chronic Obstructive Lung Disease stages provided consistent results. The addition of the panel of three biomarkers to the BODE index generated a net reclassification improvement of 57.9% (95% CI 21.7-92.4%) and 45.9% (95% CI 13.9-75.7%) at 3 and 5 years, respectively.Simultaneously elevated levels of adrenomedullin, arginine vasopressin and atrial natriuretic peptide are associated with increased risk of death in patients with stable COPD. @ERSpublications Simultaneously elevated levels of ADM, AVP and ANP are associated with increased risk of death in COPD

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mortality risk prediction in COPD by a prognostic biomarker panel

Stolz¹,

Meyer²,

Rakic³

et al. 2014

Eur Respir J

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“…Edema can also be present if pCO2 is elevated over 65 mmHg because of oliguria due to redistribution of renal blood flow from cortical to medullary areas of kidneys (22)(23)(24)(25). Hypoxia less than 40 mmHg of PO2 can also cause renal vasoconstriction and subsequent oliguria and edema (23).…”

Section: Peripheral Edemamentioning

confidence: 99%

Physical Diagnosis of Chronic Obstructive Pulmonary Disease

Tokuda

Miyagi²

2007

Intern. Med.

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“…(1) Severe intravascular hypovolemia results in a decreased cardiac output, tissue hypoperfusion and organ dysfunction. (2,3) Therefore, perioperative fluid management should avoid these complications via replacing blood and fluid losses as adequately as possible.…”

Section: …………………………………………………………………………………………………… Introduction:-mentioning

confidence: 99%