Fluid Fluorocarbon as Oxygenator in Experimental Extracorporeal Circulation

Howlett, Stephen A.

doi:10.1001/archsurg.1965.01320160097023

Cited by 34 publications

(7 citation statements)

References 5 publications

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“…The fact that PFCs had the ability of dissolving larger amounts of gases than any other solvent was known. , What Clark and Gollan demonstrated in a spectacular fashion was that animals could withstand such treatment, i.e., that the PFC supported respiration and caused the animal no harm. Although PFCs had already been used in cellular microsurgery, in a blood oxygenator, and for isolating viruses, this experiment stimulated imagination and somewhat “officially” marked the entry of PFCs into the biomedical field. The same authors also reported that isolated rat hearts would continue to contract vigorously when perfused alternatively with an oxygenated liquid PFC and with diluted blood…”

Section: The First Generation Of Fluorocarbon Emulsions1 Groundbreakingmentioning

confidence: 99%

Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some PhysiologyBlut ist ein ganz besondrer Saft

2001

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Pharmaceutical Corporation in San Diego; however, the opinion expressed here are solely his and not necessarily those of the Corporation. Jean G. Riess received his chemical engineer and doctorat-e `s-sciences degrees (the latter with Professor Guy Ourisson in 1963) from the University of Strasbourg. He then spent two years with John Van Wazer at Monsanto in Saint-Louis, MO, learning some phosphorus and transitionmetal chemistry. In 1968 he became Professor at the University of Nice, France, where he founded, directed, and eventually became honorary director of the Unite ´de Chimie Mole ´culaire (associated with the Centre National de la Recherche Scientifique). His research successively involved phosphorus chemistry, transition-metal chemistry, organometallics, and eventually perfluorochemicals. His present interests are in fluorocarbons, fluorinated amphiphiles, and their colloid chemistry, including fluorocarbon emulsions for in vivo O 2 delivery, fluorinated self-assemblies, and drug delivery systems. Professor Riess has published about 360 papers and holds ca. 25 patents. He has served on numerous councils and committees and has chaired or co-chaired international conferences on phosphorus chemistry and blood substitutes. He has won awards from the French Academy of Sciences, French Chemical Society, Alexander von Humboldt Stifftung, City of Nice and Controlled Release Society, as well as Alliance's first Distinguished Contribution Award. He holds an honorary Research Associate position at the University of California at San Diego and sits on the Board of Directors of Alliance Pharmaceutical Corp.

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Section: The First Generation Of Fluorocarbon Emulsions1 Groundbreakingmentioning

confidence: 99%

Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some PhysiologyBlut ist ein ganz besondrer Saft

2001

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“…Several authors have developed oxygenators which abolish the blood/solid surface interface by utilizing fluorocarbon liquids (not emulsions) as the gas delivery media. [155][156][157][158] Although they are harmless to the blood elements and nonthrombogenic they are limited by a low oxygen transfer rate and they are still experimental.…”

Section: Cardiopulmonary Bypassmentioning

confidence: 99%

Fluorocarbon emulsions

Marchbank

1995

Perfusion

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Perfluorocarbon emulsions have been the topic of intense investigation for many years and presently there are still no absolute indications for their use in clinical practice. The relatively disappointing results of the early clinical studies, as a consequence of using low concentrations of a relatively underdeveloped emulsion, have been responsible for a largely negative impression and it is now essential that the newer second generation emulsions should be judged individually with regard to their efficacy and toxicity under different circumstances. Technological advancement in the fields of chemistry and detergent/emulsifier research will continue and new formulations are being developed which which will require to be tested in models in the laboratory. In the future, this class of drugs will continue to be the topic of intense investigation and their mechanisms of action, which are undoubtedly more complex than the simple carriage of dissolved gases in solution, will be clarified. However, whether fluorocarbon emulsions will ever be used as a 'blood substitute' as was originally anticipated is doubtful.

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“…Howlett 21 and co-workers in 1965 reported on an extracorporeal circulation apparatus using fluid exchange of oxygen rather than gaseous exchange in order to minimize blood trauma. Venous blood entered the bottom of concentric lucite cylinders forming a film on the wall and exited at the top.…”

Section: Lukinmentioning

confidence: 99%

Breathing of Pressure Oxygenated Fluids by Submerged Mammals: A Literature Review

Hendricks¹

1968

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Fluid Fluorocarbon as Oxygenator in Experimental Extracorporeal Circulation

Cited by 34 publications

References 5 publications

Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some PhysiologyBlut ist ein ganz besondrer Saft

Oxygen Carriers (“Blood Substitutes”)Raison d'Etre, Chemistry, and Some PhysiologyBlut ist ein ganz besondrer Saft

Fluorocarbon emulsions

Breathing of Pressure Oxygenated Fluids by Submerged Mammals: A Literature Review

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