In order to obtain the leakage characteristics of an upstream pumping face seal with inclined ellipse dimples under high-temperature and high-speed liquid lubricating conditions, a thermo-hydrodynamic lubricating model is developed. The novelty of this model is that it takes the thermo-viscosity effect and cavitation effect into account. The influence of operating parameters, such as rotational speed, seal clearance, seal pressure, ambient temperature and structural parameters, such as dimple depth, inclination angle, slender ratio and dimple number on the opening force and leakage rate, is numerically calculated. The results obtained show that the thermo-viscosity effect makes the cavitation intensity decrease noticeably, leading to an increase in the upstream pumping effect of ellipse dimples. Moreover, the thermo-viscosity effect may make both the upstream pumping leakage rate and opening force increase by about 10%. It can also be found that the inclined ellipse dimples can produce an obvious upstream pumping effect and hydrodynamic effect. Based on the reasonable design of the dimple parameter, not only can the sealed medium achieve zero leakage, but the opening force can also increase by more than 50%. The proposed model has the potential to provide the theoretical basis for and guide the future designs of upstreaming liquid face seals.