Abstract:Background: Mechanical interactions between tumor cells and microenvironments are frequent phenomena during breast cancer progression, however, it is not well understood how interactions in the magnitude of those encountered in the vascular microenvironment affect expression of genes related to Epithelial-to-Mesenchymal Transition (EMT) and adhesion to endothelial cells. EMT is associated with the progression of most carcinomas through induction of new transcriptional programs within affected epithelial cells,… Show more
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