Flufenamic Acid-Loaded Self-Nanoemulsifying Drug Delivery System for Oral Delivery: From Formulation Statistical Optimization to Preclinical Anti-Inflammatory Assessment

Abstract

Introduction Flufenamic acid FLF is chemically anthranilic acid derivative which possessing analgesic, anti-inflammatory and antipyretic properties and recommended for oral or topical administrations 1. It belongs to biopharmaceutical classification system BCS class II with low aqueous solubility 9.09 mg/L and high permeability log P 5.25 2, 3. High octanol/water partition coefficient, poor aqueous solubility and gastric disturbances are the prime deciding factors for alternate formulation development intended for oral or topical administration 4. Several approaches have been explored to enhance the solubility and dissolution of FLF including solid dispersion 5, 6 , inclusion complex 3, 7 and cocrystal 2. However, lipid based nanocarrier could be a promising technique for improved solubilization, increased

A novel nasal co-loaded loratadine and sulpiride nanoemulsion with improved downregulation of TNF-α, TGF-β and IL-1 in rabbit models of ovalbumin-induced allergic rhinitis

“…The electrical conductivity of the selected nanoemulsions revealed good quality nanoemulsions and support stability (Sari et al, 2015). The enhanced release of loratadine and sulpiride from F2 and F3 compared to the corresponding raw rugs could be ascribed to the small droplet size of the investigated nanoemulsions which imparts large surface area for release (Alshehri et al, 2020). Thus, both drugs existed in solubilized micellar solution which greatly enhanced their release from the selected nanoemulsions (Balata, 2018).…”

Improved Pharmacodynamic Potential of Rosuvastatin by Self-Nanoemulsifying Drug Delivery System: An in vitro and in vivo Evaluation

“…A suitable quantity of pure rosuvastatin, physical mixture (rosuvastatin + Capmul MCM EP + Tween 20 + Transcutol P) and rosuvastatin-loaded SNEDDS was compressed for 5 min at 5 bars on a KBr press and the samples were scanned on the wavenumber range of 400-4400 cm −1 . 42 Test for % Transmittance It was estimated for the detection of in vivo effect on the solubilization of the capacity of drug subsequent to dilution in the lumen of the gut. During their development for oral route, there are possibilities for a decline in solubilization capacity that will result in precipitation of the drug.…”