Fluence-based relative biological effectiveness for charged particle carcinogenesis in mouse Harderian gland

Alpen, Edward L.; Powers-Risius, P.; Curtis, Stanley B.; DeGuzman, Randy J.; Fry, R.J.M.

doi:10.1016/0273-1177(94)90512-6

Cited by 87 publications

(49 citation statements)

References 6 publications

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“…This corresponds to data from the study of Alpen et al (44), who measured charged particle tumor induction in the Harderian glands of mice. They found that, for LET values of 100 keV/mm and greater, one traversal through the cell nucleus may lead to transformation.…”

Section: Dependence On Target Sizesupporting

confidence: 87%

Neoplastic Transformation Induced by Carbon Ions

Bettega

Calzolari

Hessel³

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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Section: Dependence On Target Sizesupporting

confidence: 87%

Neoplastic Transformation Induced by Carbon Ions

Bettega

Calzolari

Hessel³

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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“…Histopathological analysis indicated that most of these masses were adenomas or adenocarcinomas arising from within the harderian glands of the mice; thus they are referred to here as harderian gland tumors. Harderian gland tumors have been reported and studied extensively in radiation carcinogenesis studies in rodents (26)(27)(28). It is noteworthy that the malignant harderian gland tumors (adenocarcinomas) were observed only in proton-or ironion-irradiated animals maintained on the control diet, while no malignant harderian gland tumors were observed in the proton-or iron-ion-irradiated animals maintained on the antioxidant-or BBIC-supplemented diets.…”

Section: Long-term Studiesmentioning

confidence: 93%

Effects of Dietary Antioxidant Supplementation on the Development of Malignant Lymphoma and Other Neoplastic Lesions in Mice Exposed to Proton or Iron-Ion Radiation

et al. 2008

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Malignancy is considered to be a particular risk associated with exposure to the types of ionizing radiation encountered during extended space flight. In the present study, two dietary preparations were evaluated for their ability to prevent carcinogenesis in CBA mice exposed to different forms of space radiation: protons and highly energetic heavy particles (HZE particles). One preparation contained a mixture of antioxidant agents. The other contained the soybean-derived Bowman-Birk protease inhibitor (BBI), used in the form of BBI Concentrate (BBIC). The major finding was that there was a reduced risk of developing malignant lymphoma in animals exposed to space radiation and maintained on diets containing the antioxidant formulation or BBIC compared to the irradiated animals maintained on the control diet. In addition, the two different dietary countermeasures also reduced the yields of a variety of different rare tumor types observed in the animals exposed to space radiation. These results suggest that dietary supplements could be useful in the prevention of malignancies and other neoplastic lesions developing from exposure to space radiation.

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“…It was assumed that only single primary particles contribute to ionization clusters. This assumption is justified by the small geometric cross section of the nanodosimetric SV and the low-dose/fluence space radiation environment [31]. For example, 32 protons of 250 MeV traversing a typical mammalian cell of 20 mm 2 cross section deliver a dose of 0.1 Gy.…”

Section: Article In Pressmentioning

confidence: 99%