Compelling efforts to improve the critical temperature (T c ) of superconductors have been made through high-pressure application. Understanding the underlying mechanism behind such improvements is critically important, however, much remains unclear. Here we studied ortho-III YBa 2 Cu 3 O 6.73 (YBCO) using x-ray scattering under hydrostatic-pressure (HP) up to ~6.0 GPa. We found the reinforced oxygen order (OO) of YBCO under HP, revealing an oxygen rearrangement in the Cu-O layer, which evidently shows the charge transfer phenomenon between the CuO 2 plane and Cu-O layer. Concurrently, we also observed no disorder-pinned charge density wave (CDW) signature in CuO 2 plane under HP. This indicates that the oxygen rearrangement modifies the quenched disorder state in the CuO 2 plane.Using these results, we appropriately explain why pressure-condition can achieve higher T c compared with the optimal T c under ambient pressure in YBa 2 Cu 3 O 6+x . As an implication of these results, finally, we have discussed that the change in disorder could make it easier for YBa 2 Cu 3 O 6+x to undergo a transition to the nematic order under an external magnetic field.