Fluctuating into a biofilm

Budrikis, Zoe

doi:10.1038/s42254-022-00531-6

Cited by 1 publication

(2 citation statements)

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“…[ 4,5 ] In addition to the acquisition of genetic mutations to develop drug‐resistant bacterial strain or species, forming a stubborn fortress known as biofilm to defend attacks from antibiotics and immune systems is another important trick that most sly pathogenic bacteria frequently utilize to survive. [ 6–8 ]…”

Section: Introductionmentioning

confidence: 99%

“…[4,5] In addition to the acquisition of genetic mutations to develop drug-resistant bacterial strain or species, forming a stubborn fortress known as biofilm to defend attacks from antibiotics and immune systems is another important trick that most sly pathogenic bacteria frequently utilize to survive. [6][7][8] Bacterial biofilms are multicellular 3D assemblages with diverse surface-attached bacterial cells encased by the self-secreted extracellular polymeric substances (EPS), and it can completely establish after going through four main stages in terms of initial adhesion, early biofilm formation, biofilm maturation, and dispersal. [9,10] As an emergent form of bacterial life, the obstinate biofilms are extensively existed and have significant impacts on a range of application scenarios, for instance, it has been estimated that up to an approximated 80% of all microbial infections are associated with the formation of disturbing biofilms in the realm of healthcare.…”

Section: Introductionmentioning

confidence: 99%

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Emerging Applications of Aggregation‐Induced Emission Luminogens in Bacterial Biofilm Imaging and Antibiofilm Theranostics

Liu

Kang

et al. 2023

Small Structures

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Threats posed by recalcitrant bacterial biofilms have been continuously challenging the public health due to the dramatically magnified antibiotic resistance resulted from the complicated biofilm microenvironment. Urgent demands on effective biofilm combating have propelled the rapid exploration of high‐performance antibiofilm systems. Thanks to the distinguished features of aggregation‐intensified fluorescence and aggregation‐enhanced generation of reactive oxygen species, aggregation‐induced emission luminogens (AIEgens) are becoming increasingly eye‐catching in the field of biofilm combating by serving as excellent fluorescence imaging probes or theranostic agents. This review aims to, for the first time, outline the current progress of AIEgens in bacterial biofilm imaging and antibiofilm theranostics. The up‐to‐date advancements of AIEgens in enzyme‐responsive biofilm imaging, discriminative imaging of Gram‐positive bacterial biofilm, as well as biofilm viability monitoring are summarized at first. Subsequently, the antiadhesion intervention‐mediated prevention of biofilm formation and photodynamic therapy‐involved eradication of preexisting biofilms are detailedly elucidated. Finally, a brief conclusion as well as a discussion on the current challenges and future expectations is presented.

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Section: Introductionmentioning

confidence: 99%