Fluconazole encapsulation in PLGA microspheres by spray-drying

Rivera, Paula Angarita; Martínez-Ohárriz, María Cristina; Rubio, M.; Irache, Juan M.; Espuelas, Socorro

doi:10.1080/02652040310001637811

Cited by 43 publications

(23 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results are in good agreement with a previous report that at low nominal drug loading, fluconazole was incorporated in an amorphous state or in a molecular dispersion in the microsphere matrix, but at high nominal drug loading, part of the drug was in a crystalline form. 27 LeCorre et al 26 have also observed relatively highly loaded drug existing in a particulate dispersion instead of a molecular dispersion.…”

Section: Influence Of Drug Loading On Microsphere Propertiesmentioning

confidence: 95%

Influence of morphology and drug distribution on the release process of FITC-dextran-loaded microspheres prepared with different types of PLGA

Cai

Mao

Germershaus

et al. 2008

Journal of Microencapsulation

View full text Add to dashboard Cite

The aim of the present work was to understand the collaborative roles and the comprehensive effects of polymer nature, morphology, drug distribution and release behaviour for PLGA microspheres prepared by the double emulsion method. The morphology and drug distribution of the FITC-dextran-loaded microspheres were investigated by scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM), respectively. The results show that the morphology and release profiles depend on the polymer nature. For the capped PLGA RG502, the porosity, pore size and drug distribution had no pronounced influence on the release profile beyond the initial release. No significant changes in size and morphology were found and there was negligible water uptake during the release process. PEG addition as a pore maker indicated a possible way to modify the release rate at the second release stage. However, in the case of the uncapped PLGA RG503H, release profiles were dependent upon changes in porosity, pore size and drug loading. Increases in porosity, internal pore size and loading resulted in a continuous release profile. Previous studies have shown the importance of different process parameters on morphology and drug release, but in this work it is clear that polymer nature is a determining factor.

show abstract

Section: Influence Of Drug Loading On Microsphere Propertiesmentioning

confidence: 95%

Influence of morphology and drug distribution on the release process of FITC-dextran-loaded microspheres prepared with different types of PLGA

Cai

Mao

Germershaus

et al. 2008

Journal of Microencapsulation

View full text Add to dashboard Cite

show abstract

“…Pure water is then added to allow the solvent to diffuse into the aqueous phase leading to the formation of particles. This method allows for better control of the particle size, by controlling the stabilizer concentration, the stirring rate and the polymer concentration [22,23]. However, an additional purification step is necessary to remove the electrolyte used for the saturation of the aqueous phase.…”

Section: Preparation Of Pla/plga Particlesmentioning

confidence: 99%

Poly(Lactic Acid) and Poly(Lactic- Co -Glycolic Acid) Particles as Versatile Carrier Platforms for Vaccine Delivery

Pavot

Berthet

Rességuier

et al. 2014

Nanomedicine (Lond.)

103

View full text Add to dashboard Cite

The development of safe and effective vaccines for cancer and infectious diseases remains a major goal in public health. Over the last two decades, controlled release of vaccine antigens and immunostimulant molecules has been achieved using nanometer or micron-sized delivery vehicles synthesized using biodegradable polymers. In addition to achieving a depot effect, enhanced vaccine efficacy using such delivery vehicles has been attributed to efficient targeting of antigen presenting cells such as dendritic cells. Biodegradable and biocompatible poly(lactic acid) and poly(lactic-co-glycolic acid) polymers belong to one such family of polymers that have been a popular choice of material used in the design of these delivery vehicles. This review summarizes research findings from ourselves and others highlighting the promise of poly(lactic acid)- and poly(lactic-co-glycolic acid)-based vaccine carriers in enhancing immune responses.

show abstract

“…Many approaches are proposed for the preparation of PLGA particles. The emulsification-evaporation method [64][65][66][67], spontaneous emulsificationsolvent diffusion method (SESD) [20,68], nanoprecipitation method [69,70] and spray-drying [71][72][73] are all widely used in preparing PLGA particles of various sizes. Each of these methods employs a similar first step, where an aqueous drug solution is emulsified in an organic polymer solution to form a water-in-oil dispersion (W 1 /O).…”

Section: Formulation Aspects Of Micro and Nano Po-lymeric Particlesmentioning

confidence: 99%

Poly(lactide-co-glycolide)-based Micro and Nanoparticles for the Controlled Drug Delivery of Vitamins

Uskokovic¹,

Stevanović²

2009

CNANO

143

View full text Add to dashboard Cite

Controlled drug delivery systems and polymeric carriers have undergone significant development in recent years. Polymers like polylactides (PLA), polyglycolides (PGA), poly(lactide-co-glycolides) (PLGA), are approved by the World Health Organization (WHO) and Food and Drug Administration (FDA) as materials that can be used in medicine and pharmacy. Owing to their biodegradable nature, polymer materials, such as copolymer poly(DL-lactide-co-glycolide), are widely used in various medical applications; controlled release of delivering drugs, carriers in the tissue engineering, fixation of bone fractures, chirurgical strings, etc. Polymeric particles are used for the controlled delivery of several types of medicaments, including anticancer agents, antihypertensive agents, immunomodulatory drugs, hormones, vitamins and macromolecules, such as nucleic acid, proteins, peptides, antibodies, etc. Preparation of poly(lactideco-glycolide) submicron spheres poses serious challenges. The present review attempts to address some important issues related to micro/nanoparticle-based delivery systems comprising poly(lactide-co-glycolide), with a special reference to PLGA for the controlled delivery of vitamins. A range of topics is discussed, including formulation aspects of micro-and nanoparticles, the effects of particle size and size distribution, most commonly used incorporation techniques, surface modification with stabilizers, surface funcionalization, and factors affecting degradation and drug release rate.

show abstract

Fluconazole encapsulation in PLGA microspheres by spray-drying

Cited by 43 publications

References 10 publications

Influence of morphology and drug distribution on the release process of FITC-dextran-loaded microspheres prepared with different types of PLGA

Influence of morphology and drug distribution on the release process of FITC-dextran-loaded microspheres prepared with different types of PLGA

Poly(Lactic Acid) and Poly(Lactic- Co -Glycolic Acid) Particles as Versatile Carrier Platforms for Vaccine Delivery

Poly(lactide-co-glycolide)-based Micro and Nanoparticles for the Controlled Drug Delivery of Vitamins

Contact Info

Product

Resources

About