Fluconazole as Schistosoma mansoni cytochrome P450 inhibitor: In vivo murine experimental study

Elzoheiry, Manal; Elmehankar, Manar S.; Aboukamar, Wafaa A.; El-Gamal, Randa; Sheta, Heba; Zenezan, Dina; Nabih, Nairmen; Elhenawy, Abeer A.

doi:10.1016/j.exppara.2022.108291

Cited by 3 publications

(2 citation statements)

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“…Their derivatives have been extensively used in many medicinal scaffolds. For example, Itraconazole, [ 62 ] Fluconazole, [ 63 ] and Voriconazole [ 64 ] are usually applied antifungals in clinical applications. Ribavirin [ 65 ] is an antiviral drug applied for hepatitis.…”

Section: Triazolesmentioning

confidence: 99%

An overview of the privileged synthetic heterocycles as urease enzyme inhibitors: Structure–activity relationship

Sepehri,

Khedmati

2023

Archiv der Pharmazie

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Urease is a metalloenzyme including two Ni2+ ions, found in some plants, bacteria, fungi, microorganisms, invertebrate animals, and animal tissues. Urease acts as a significant virulence factor, mainly in catheter blockage and infective urolithiasis as well as in the pathogenesis of gastric infection. Therefore, studies on urease lead to novel synthetic inhibitors. In this review, the synthesis and antiurease activities of a collection of privileged synthetic heterocycles such as (thio)barbiturate, (thio)urea, dihydropyrimidine, and triazol derivatives were described and discussed according to structure–activity relationship findings in search of the best moieties and substituents that are answerable for encouraging the desired activity even more potent than the standard. It was found that linking substituted phenyl and benzyl rings to the heterocycles led to potent urease inhibitors.

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Section: Triazolesmentioning

confidence: 99%

An overview of the privileged synthetic heterocycles as urease enzyme inhibitors: Structure–activity relationship

Sepehri,

Khedmati

2023

Archiv der Pharmazie

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“…Their derivatives have been widely applied in many medicinal scaffolds ( Figure 1 ;2 and (c)). For example, Itraconazole ( Navarro-Triviño, 2021 ; Neto et al, 2022 ), Fluconazole ( Elzoheiry et al, 2022 ; Gao et al, 2022 ), and Voriconazole ( Shettar et al, 2021 ; Lindsay et al, 2022 ) are commonly used antifungals in clinical application. Ribavirin ( Burman et al, 2022 ; Tian et al, 2022 ) is a broad-spectrum antiviral drug used in the treatment of hepatitis.…”

Section: Introductionmentioning

confidence: 99%

Synthesis methods of 1,2,3-/1,2,4-triazoles: A review

et al. 2022

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Triazole, comprising three nitrogen atoms and two carbon atoms, is divided into two isomers 1,2,3-triazole and 1,2,4-triazole. Compounds containing a triazole are one of the significant heterocycles that exhibit broad biological activities, such as antimicrobial, analgesic, anti-inflammatory, anticonvulsant, antineoplastic, antimalarial, antiviral, antiproliferative, and anticancer activities. A great quantity of drugs with a triazole structure has been developed and proved, for example, ketoconazole and fluconazole. Given the importance of the triazole scaffold, its synthesis has attracted much attention. This review summarizes the synthetic methods of triazole compounds from various nitrogen sources in the past 20 years.

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Research progress in the treatment of schistosomiasis with traditional Chinese medicine

Xiang,

Zhang,

et al. 2024

Journal of Ethnopharmacology

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Fluconazole as Schistosoma mansoni cytochrome P450 inhibitor: In vivo murine experimental study

Cited by 3 publications

References 34 publications

An overview of the privileged synthetic heterocycles as urease enzyme inhibitors: Structure–activity relationship

An overview of the privileged synthetic heterocycles as urease enzyme inhibitors: Structure–activity relationship

Synthesis methods of 1,2,3-/1,2,4-triazoles: A review

Research progress in the treatment of schistosomiasis with traditional Chinese medicine

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