2016
DOI: 10.1002/eji.201545929
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Flt3 ligand improves the innate response to respiratory syncytial virus and limits lung disease upon RSV reexposure in neonate mice

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Cited by 28 publications
(53 citation statements)
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“…Activated IRF3 and IRF7 translocate to the nucleus to transactivate IFN-α and IFN-β gene expression. TLR3 activation in macrophages during RSV infection (Tsai et al, 2015) culminates in IFN-β expression/production, by virtue of IRF3 and IRF7 activation (Casola et al, 2001; Jewell et al, 2007; Sabbah et al, 2009; Remot et al, 2016). In that regard, IRF7 is required for IFN-β gene expression following TLR3 activation (Siednienko et al, 2012).…”
Section: Discussionmentioning
confidence: 99%
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“…Activated IRF3 and IRF7 translocate to the nucleus to transactivate IFN-α and IFN-β gene expression. TLR3 activation in macrophages during RSV infection (Tsai et al, 2015) culminates in IFN-β expression/production, by virtue of IRF3 and IRF7 activation (Casola et al, 2001; Jewell et al, 2007; Sabbah et al, 2009; Remot et al, 2016). In that regard, IRF7 is required for IFN-β gene expression following TLR3 activation (Siednienko et al, 2012).…”
Section: Discussionmentioning
confidence: 99%
“…IRF7 is a virus specific IFN-β inducer operating during MyD88-independent TLR signaling (e.g., TLR3 signaling) (Honda et al, 2005). RSV induces IRF7 expression in cells and mice respiratory tract (Casola et al, 2001; Jewell et al, 2007; Remot et al, 2016). Furthermore, IRF7 is constitutively expressed (and induced following virus infection) in primary macrophages and macrophage cell-lines like RAW 264.7 cells (Wilden et al, 2009; Ning et al, 2011).…”
Section: Discussionmentioning
confidence: 99%
“…Also, a deficiency in type I IFN production by cells from infants 47 and from neonatal mice 48, 49 has been shown. In contrast, some studies show a higher level of IFN-α in nasopharyngeal wash in more severely sick infants compared to controls 50 .…”
Section: Innate Immune Responses To Rsvmentioning
confidence: 99%
“…They are activated by PRR signalling and pro-inflammatory mediators in the lung to increase their antigen processing and presentation capability and migrate to regional lymph nodes where they convey viral antigens to naïve T and B cells 83 . It is interesting to note that there are fewer DCs in the lungs and lymph nodes of infants and they are also less functional after RSV infection compared to those from adult lungs 49, 84, 85 . Also, fewer and less functional plasmacytoid DCs are found in young children 47, 86 .…”
Section: Adaptive Immune Responses To Rsvmentioning
confidence: 99%
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