Review on t(12;13)(p13;q12) ETV6/FLT3, with data on clinics, and the genes implicated.
Clinics and pathology
DiseaseAcute lymphoblastic leukemia (ALL) and myeloid malignancies are described in cases of t(12;13)(p13;q12) Note The translocation t(12;13)(p13;q12) is molecularly heterogeneous: The t(12;13)(p13;q12) with ETV6 and FLT3 involvement, herein described, was found in three cases of myeloproliferative neoplasm (MPN) with eosinophilia (Vu et al., 2006; Walz et al., 2011). On the other hand, a t(12;13)(p13;q12) ETV6/CDX2 has been described in another case (Chase et al., 1999). Finally, other cases of t(12;13)(p13;q12) without molecular ascertainment may or may not involve FLT3, CDX2, or even ETV6.
EpidemiologyAll together, eleven cases of t(12;13)(p13;q12) were described.
Clinics