Flower-like Surface of Three-Metal-Component Layered Double Hydroxide Composites for Improved Antibacterial Activity of Lysozyme

Wang, Zhuo; Yu, Hao; Ma, Kun; Chen, Yuzhi; Zhang, Xiuquan; Wang, Tongxin; Li, Sanbao; Zhu, Xiaoqun; Wang, Xuefei

doi:10.1021/acs.bioconjchem.8b00305

Cited by 36 publications

(20 citation statements)

References 46 publications

(74 reference statements)

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“…The thermal stability and antibacterial activity against some clinically important bacterial pathogens, namely Bacillus subtilis , Pseudomonas aeruginosa , Staphylococcus aureus , and Escherichia coli was proven for a polyacrylonitrile/Zn-Al LDHs nanocomposite [ 25 , 26 ]. Wang et al (2018) prepared various types of lysozyme modified LDHs which exhibited excellent antibacterial activity and wound healing ability [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Toxicity of Zn-Fe Layered Double Hydroxide to Different Organisms in the Aquatic Environment

et al. 2021

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The application of layered double hydroxide (LDH) nanomaterials as catalysts has attracted great interest due to their unique structural features. It also triggered the need to study their fate and behavior in the aquatic environment. In the present study, Zn-Fe nanolayered double hydroxides (Zn-Fe LDHs) were synthesized using a co-precipitation method and characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and nitrogen adsorption-desorption analyses. The toxicity of the home-made Zn-Fe LDHs catalyst was examined by employing a variety of aquatic organisms from different trophic levels, namely the marine photobacterium Vibrio fischeri, the freshwater microalga Pseudokirchneriella subcapitata, the freshwater crustacean Daphnia magna, and the duckweed Spirodela polyrhiza. From the experimental results, it was evident that the acute toxicity of the catalyst depended on the exposure time and type of selected test organism. Zn-Fe LDHs toxicity was also affected by its physical state in suspension, chemical composition, as well as interaction with the bioassay test medium.

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Section: Introductionmentioning

confidence: 99%

Toxicity of Zn-Fe Layered Double Hydroxide to Different Organisms in the Aquatic Environment

et al. 2021

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“…However, the effect of silver combined with CFZ or NAL on the last bacterium is enhanced when the two antimicrobials are immobilized on the LDH. Indeed, the positive charge of the LDH surface is able to attract negatively charged bacterial cells by promoting bacterial adhesion on LDH, and the close contact between the antimicrobial agents and the bacteria supports the action of the active species [ 49 ].…”

Section: Resultsmentioning

confidence: 99%

Overcoming Antibiotic Resistance: Playing the ‘Silver Nanobullet’ Card

et al. 2022

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Enhancing the antibacterial activity of old antibiotics by a multitarget approach, such as combining antibiotics with metal nanoparticles, is a valuable strategy to overcome antibacterial resistance. In this work, the synergistic antimicrobial effect of silver nanoparticles and antibiotics, immobilized on a solid support, was investigated. Nanometric layered double hydroxides (LDH) based on Zn(II) and Al(III) were prepared by the double microemulsion technique. The dual function of LDH as an anionic exchanger and support for metal nanoparticles was exploited to immobilize both silver and antibiotics. Cefazolin (CFZ), a β-lactam, and nalidixic acid (NAL), a quinolone, were selected and intercalated into LDH obtaining ZnAl-CFZ and ZnAl-NAL samples. These samples were used for the growth of silver nanoparticles with dimension ranging from 2.5 to 8 nm. Silver and antibiotics release profiles, from LDH loaded with antibiotics and Ag/antibiotics, were evaluated in two different media: water and phosphate buffer. Interestingly, the release profiles are affected by both the acceptor media and the presence of silver. The synergistic antibacterial activity of LDH containing both silver and antibiotics were investigated on gram-positives (Staphylococcus aureus and Streptococcus pneumoniae) and gram-negatives (Pseudomonas aeruginosa) and compared with the plain antimicrobials and LDH containing only antibiotics or silver.

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“…In addition to the above-mentioned 2D NBG antibacterial nanomaterials, some other new members of 2D nanomaterials, such as layered double hydroxides (LDHs) 213-216, laponite (Lap) 217, 218, hexagonal boron nitride (BN) 176, III 2 -VI 3 compounds (In 2 Se 3 , Bi 2 Se 3 , Sb 2 Se 3 ) 90, 177, 219, 220, and RuO 2 have also been deemed as promising antibacterial agents. For example, Wang et al prepared various morphology of lysozyme modified LDHs through tuning the ratio of cations, and found that bloom flower structure of LDHs not only could load more lysozyme but also adhere to more bacteria, which show excellent antibacterial activity and wound healing ability 175. Moreover, Ghadiri et al fabricated a Laponite/mafenide/alginate (Lap/Maf/Alg) film with remarkable antibacterial effects and good wound healing applications 221.…”

Section: 2d Nbg Antibacterial Nanomaterialsmentioning

confidence: 99%

Two-dimensional nanomaterials beyond graphene for antibacterial applications: current progress and future perspectives

et al. 2020

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The marked augment of drug-resistance to traditional antibiotics underlines the crying need for novel replaceable antibacterials. Research advances have revealed the considerable sterilization potential of two-dimension graphene-based nanomaterials. Subsequently, two-dimensional nanomaterials beyond graphene (2D NBG) as novel antibacterials have also demonstrated their power for disinfection due to their unique physicochemical properties and good biocompatibility. Therefore, the exploration of antibacterial mechanisms of 2D NBG is vital to manipulate antibacterials for future applications. Herein, we summarize the recent research progress of 2D NBG-based antibacterial agents, starting with a detailed introduction of the relevant antibacterial mechanisms, including direct contact destruction, oxidative stress, photo-induced antibacterial, control drug/metallic ions releasing, and the multi-mode synergistic antibacterial. Then, the effect of the physicochemical properties of 2D NBG on their antibacterial activities is also discussed. Additionally, a summary of the different kinds of 2D NBG is given, such as transition-metal dichalcogenides/oxides, metal-based compounds, nitride-based nanomaterials, black phosphorus, transition metal carbides, and nitrides. Finally, we rationally analyze the current challenges and new perspectives for future study of more effective antibacterial agents. This review not only can help researchers grasp the current status of 2D NBG antibacterials, but also may catalyze breakthroughs in this fast-growing field.

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Flower-like Surface of Three-Metal-Component Layered Double Hydroxide Composites for Improved Antibacterial Activity of Lysozyme

Cited by 36 publications

References 46 publications

Toxicity of Zn-Fe Layered Double Hydroxide to Different Organisms in the Aquatic Environment

Toxicity of Zn-Fe Layered Double Hydroxide to Different Organisms in the Aquatic Environment

Overcoming Antibiotic Resistance: Playing the ‘Silver Nanobullet’ Card

Two-dimensional nanomaterials beyond graphene for antibacterial applications: current progress and future perspectives

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