Flow versus batch detection of radioactivity in column liquid chromatography

Sieswerda, G. B.; Poppe, H.; Huber, J.F.K.

doi:10.1016/s0003-2670(00)00154-9

Cited by 24 publications

(3 citation statements)

References 5 publications

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“…[35][36][37][38][39][40][41][42][43] The first coupling of a radioactivity detector to HPLC was performed by Sieswerda and Polak. [44,45] Using different solid scintillation materials incorporated into a U-shaped on-line detection cell, they compared off-line and on-line radioactivity detection. Theoretical considerations revealed how the precision in on-line counting depends on the sample count rate, background count rate and the residence time in the cell.…”

Section: On-line Radioactivity Detectionmentioning

confidence: 99%

Radioactivity Detectors for High-Performance Liquid Chromatography in Drug Metabolism Studies

Kiffe

Schmid

Bruin

2008

Journal of Liquid Chromatography & Related Technologies

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Sensitive radioactivity detection following high performance liquid chromatography (HPLC) remains a challenge in drug metabolism studies with radiolabeled compounds. The aim of this review article is to give a general overview of scintillation counting techniques and to summarize recent advances in radioactivity detection for HPLC, with a strong emphasis on the application in drug metabolism studies. State of the art and new developments with homogeneous and heterogeneous on-line radioactivity detectors, stop-flow technology, off-line microplate solid scintillation counters (SSC), and accelerator mass spectrometry (AMS) will be discussed.

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Section: On-line Radioactivity Detectionmentioning

confidence: 99%

Radioactivity Detectors for High-Performance Liquid Chromatography in Drug Metabolism Studies

Kiffe

Schmid

Bruin

2008

Journal of Liquid Chromatography & Related Technologies

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“…On-line radioactivity detectors were designed for automatic amino acid analyzers [31], and for column chromatography systems [32][33][34][35][36][37][38] before highperformance liquid chromatographs became readily available. These helped to lay the groundwork for the development of HPLC on-line detectors.…”

Section: Basic Equipment Descriptionmentioning

confidence: 99%

Other Modes of Detection

Parriott

1993

A Practical Guide to HPLC Detection

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“…An ESR detector monitors stable free radicals (480); heat-of-absorption detectors are sometimes applicable (610); radioactivity flow detectors are compared (513). Gas-chromatography detectors, flame ionization (4, 524), and electron capture (624) are used with moving wires to transfer the solutes while removing the solvent.…”

Section: Nonchromatographic Uses Of Resins and Absorbentsmentioning

confidence: 99%

Ion exchange and liquid column chromatography

Walton¹

1976

Anal. Chem.

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This year the reviews of ion exchange and of liquid column chromatography are combined. It was logical to do this, for the techniques of high-performance liquid .chromatography include the use of ion exchangers. For one reviewer to report on two years' advances in liquid chromatography as well as in ion exchange is, however, a formidable task. It was made somewhat easier by the decision to include ion-exchanging thin-layer and paper chromatography in another review. "Liquid ion exchangers" are likewise omitted except for a few references to partition chromatography.To cite all the literature references in the two overlapping fields of ion exchange and liquid column chromatography is clearly impossible. Computer print-outs can be obtained from the abstract services, but a reviewer should do more than merely copy these lists. I preferred to peruse the Harold F. Walton joined the staff of the University of Colorado in 1947. His research interests in ion exchange date from 1938 when he went to work for the Permutit Co. as a research chemist; from there he went to Northwestern University in 1940. He obtained the BA and DPhil degrees at Oxford University. He is the author of three textbooks on inorganic and analytical chemistry and coauthor with William Rieman III of "Ion Exchange in Analytical Chemistry" published in 1970. He has contributed chapters on the physical and analytical chemistry of ion exchange to several cooperative works. In 1961 he was chairman of the Gordon Research Conference on Ion Exchange. Dr. Walton spent the 1966-67 academic year and half of 1970 as a Fulbright visiting professor at the University of Trujillo, Peru. He was a member of the Advisory Board of Analytical Chemistry.

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Flow versus batch detection of radioactivity in column liquid chromatography

Cited by 24 publications

References 5 publications

Radioactivity Detectors for High-Performance Liquid Chromatography in Drug Metabolism Studies

Radioactivity Detectors for High-Performance Liquid Chromatography in Drug Metabolism Studies

Other Modes of Detection

Ion exchange and liquid column chromatography

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