Flow-Rates and Electrolytes in Minor-Salivary-Gland Saliva in Normal Subjects and Patients With Cystic Fibrosis

U, Wiesmann; Boat, ThomasF.; Sant'agnese, PaulA. Di

doi:10.1016/s0140-6736(72)91906-x

Cited by 53 publications

(30 citation statements)

References 10 publications

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“…Minor salivary glands are also affected. Elevated levels of sodium and a decrease in flow rate were reported for these glands in CF patients (Wiesman et al ., 1972). However, the parotid saliva of CF patients does not demonstrate qualitative changes as compared with that of healthy individuals.…”

mentioning

confidence: 91%

The Diagnostic Applications of Saliva— A Review

Kaufman

Lamster

2002

Critical Reviews in Oral Biology & Medicine

793

618

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This review examines the diagnostic application of saliva for systemic diseases. As a diagnostic fluid, saliva offers distinctive advantages over serum because it can be collected non-invasively by individuals with modest training. Furthermore, saliva may provide a cost-effective approach for the screening of large populations. Gland-specific saliva can be used for diagnosis of pathology specific to one of the major salivary glands. Whole saliva, however, is most frequently used for diagnosis of systemic diseases, since it is readily collected and contains serum constituents. These constituents are derived from the local vasculature of the salivary glands and also reach the oral cavity via the flow of gingival fluid. Analysis of saliva may be useful for the diagnosis of hereditary disorders, autoimmune diseases, malignant and infectious diseases, and endocrine disorders, as well as in the assessment of therapeutic levels of drugs and the monitoring of illicit drug use.

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confidence: 91%

The Diagnostic Applications of Saliva— A Review

Kaufman

Lamster

2002

Critical Reviews in Oral Biology & Medicine

793

618

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“…First, labial salivary glands consist primarily of mucous acini (1), and thus may serve as models for mucous glands of the tracheal-bronchial tree. Second, labial glands are affected in CF, as indicated by the disease-related increase in labial saliva Na concentration (2) and by histopathological findings (3,4). Third, the glands are easily available by labial biopsy.…”

Section: Introductionmentioning

confidence: 99%

Electron microprobe analysis of human labial gland secretory granules in cystic fibrosis.

Izutsu¹,

Johnson²,

Schubert³

et al. 1985

J. Clin. Invest.

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X-ray microanalysis of freeze-dried labial gland cryosections revealed that Na concentration was doubled and the Ca/S concentration ratio was decreased in secretory granules of labial glands from patients with cystic fibrosis (CF) when compared with glands from normal subjects. Other results suggested that the decrease in the Ca/S concentration ratio resulted from an increase in S concentration. These findings imply that mucous granules in labial saliva showed a CFrelated increase in Na and S content, and such changes would be expected to affect the rheology of the mucus after exocytosis. In contrast with a previous study in human parotid glands, no evidence was found for CF-related changes in cytoplasmic or nuclear Na, K, and Ca concentrations. Significant elemental differences were found between secretory granules and nuclei and cytoplasm of control cells.

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“…Both saliva (8)(9)(10)22) and sweat (8) retroinjected into the rat parotid gland were reported to inhibit Na+ reabsorption in this tissue. An evaluation of these results is beyond the scope ofthis discussion, but it seems peculiar that these secretions should be effective in inhibiting Na+ transport in the rat parotid gland when no significant abnormalities in electrolyte content in secretions from the same organ in CF subjects has been identified (12,14), but it may not be the CF parotid gland that secretes an inhibitory substance (23). In contrast to many of the preparations used previously to assay for the presence of inhibitory factors, particularly those requiring retroinjection, the present microperfusion system seems more direct and perhaps better controlled.…”

Section: Discussionmentioning

confidence: 99%