Flow-Mediated Dilation in Athletes

Montero, David; Padilla, Jaume; Díaz-Cañestro, Candela; Muris, Dennis M.J.; Pyke, Kyra E.; Obert, Philippe; Walther, Guillaume

doi:10.1249/mss.0000000000000341

Cited by 46 publications

(38 citation statements)

References 58 publications

(118 reference statements)

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“…Our finding does not confirm the results presented in a recent meta-analysis [23], which indicated that greater FMD values in athletes were observed in master athletes but not in subgroup of young athletes. The population investigated in our study constituted young athletes at age of less than 40 years.…”

Section: Discussioncontrasting

confidence: 99%

Effect of Regular Aerobic Activity in Young Healthy Athletes on Profile of Endothelial Function and Platelet Activity

Podgórska

Derkacz

Szahidewicz-Krupska

et al. 2017

BioMed Research International

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The aim of the study was to assess the impact of regular professional sports activity on the endothelial and platelet function in young men. The studied group were 79 young men (18–40 y, 25 athletes and 54 without any regular physical activity). The nitric oxide (NO) metabolic pathway intermediates, oxidative stress markers, mediators of inflammation, and platelet aggregation were measured. Flow mediated dilation (FMD) was studied before and after intravenous 16,0 g L-arginine infusion, which was repeated after oral administration of acetylsalicylic acid (ASA-75 mg/day) for 4 days. Both groups had similar demographic characteristics. In the athletes, there was significantly higher hsCRP level, better serum lipid profile, and lower pulse pressure. Greater baseline FMD in athletes and in response to L-arginine disappeared following ASA treatment. There were no differences in the levels of the NO pathway metabolites. The control group was characterized by higher PAI-1 following ASA treatment and sICAM-1 both at baseline and after ASA, but no differences in MDA and 6-keto-PGF-1 alpha and platelet aggregation were noted. Regular professional physical activity modulates endothelial but not platelet function and may thus exert an effect on overall cardiovascular risk.

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Section: Discussioncontrasting

confidence: 99%

Effect of Regular Aerobic Activity in Young Healthy Athletes on Profile of Endothelial Function and Platelet Activity

Podgórska

Derkacz

Szahidewicz-Krupska

et al. 2017

BioMed Research International

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“…Together, our results indicate a lack of association of ADMA and any of the L-arginine analogue concentrations with the ability for O 2 muscle delivery and extraction in healthy subjects. These results provide additional support to the hypothesis that, in healthy subjects, interindividual differences inV O 2 max may not be related to any differences in endothelium-dependent vasodilatation (Montero et al, 2014. Indeed, exercise capacity is significantly associated with endothelial function in less than 50% of studies in healthy subjects after adjustment for age (Montero, 2015).…”

Section: Discussionsupporting

confidence: 70%

“…These results provide additional support to the hypothesis that, in healthy subjects, interindividual differences inV O 2 max may not be related to any differences in endothelium-dependent vasodilatation (Montero et al, 2014. These results provide additional support to the hypothesis that, in healthy subjects, interindividual differences inV O 2 max may not be related to any differences in endothelium-dependent vasodilatation (Montero et al, 2014.…”

Section: Discussionsupporting

confidence: 69%

Plasma asymmetric dimethylarginine concentrations are not related to differences in maximal oxygen uptake in endurance trained and untrained men

Pawlak-Chaouch

Boissière

Munyaneza

et al. 2018

Experimental Physiology

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New Findings What is the central question of this study?Is there an association of plasma concentration of asymmetric dimethylarginine, which is related to exercise capacity in patients with cardiovascular diseases, with oxygen delivery and subsequently exercise capacity in healthy subjects in the absence of the potentially confounding influence of inflammation and oxidative stress? What is the main finding and its importance?Plasma asymmetric dimethylarginine concentrations are not related to exercise capacity in healthy subjects, while O2 delivery in the working skeletal muscle during the maximal graded‐exercise test is not associated with any of the l‐arginine analogues. ADMA alone does not play a crucial role in local muscle perfusion and in maintaining exercise capacity. Abstract Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthesis that could limit oxygen (O2) delivery in the working skeletal muscles by altering endothelium‐dependent vasodilatation. Exercise capacity is associated with plasma ADMA concentrations in patients with cardiovascular diseases, but this issue has still not been investigated in healthy subjects. We aimed to determine whether plasma ADMA concentrations were negatively associated with exercise capacity in young healthy male subjects. Ten men with maximal oxygen uptake (V̇O2 max ) > 65 mL kg−1 min−1 were included in the high exercise capacity group (HI‐FIT), and 10 men with V̇O2 max < 45 mL kg−1 min−1 were included in the low exercise capacity group (LO‐FIT). Plasma ADMA and other l‐arginine analogue concentrations were measured before and after a maximal graded‐exercise test by liquid chromatography–tandem mass spectrometry. Microvascular O2 delivery during exercise was estimated through the pattern from the sigmoid model of muscle deoxygenation in the vastus lateralis measured by near infrared spectroscopy. V̇O2 max was 60% higher in the HI‐FIT group (median: 70.2 mL kg−1 min−1; IQR: 68.0–71.9 mL kg−1 min−1) than in the LO‐FIT group (median: 43.8 mL kg−1 min−1; IQR: 34.8–45.3 mL kg−1 min−1). Plasma ADMA concentrations did not differ between the LO‐FIT and HI‐FIT groups before (0.50 ± 0.06 vs. 0.54 ± 0.07 μmol L−1, respectively) and after the maximal incremental exercise test (0.49 ± 0.08 vs. 0.55 ± 0.03 μmol L−1, respectively). There was no significant association of plasma ADMA concentrations with the pattern of local muscle deoxygenation and exercise capacity. Exercise capacity and microvascular O2 delivery are not related to plasma ADMA concentrations in young healthy male subjects. Our findings show that ADMA does not play a crucial role in local muscle perfusion and in maintaining exercise capacity without pathological conditions.

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“…Missing standard deviations (SD) of RBCV, PV, and BV were imputed from linear regression analysis of log(SD of RBCV, PV, or BV) on log(mean RBCV, PV, or BV) from studies that reported complete data, as previously described (Marinho et al., ). A systematic appraisal of quality for observational research (SAQOR) (Ross et al., ), previously applied in meta‐analysis of observational studies evaluating the effect of ExT (Montero et al., , ,b,c), was performed to provide assessment of study quality. The SAQOR was adjusted to assess (a) the study sample, (b) quality of blood volumes assessment, (c) confounding variables, and (d) data.…”

Section: Methodsmentioning

confidence: 99%

Red cell volume response to exercise training: Association with aging

Montero

Lundby

2016

Scandinavian Med Sci Sports

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Red blood cell volume (RBCV) is a main determinant of cardiorespiratory fitness in healthy individuals. However, it remains controversial to what extent exercise training (ExT) enhances RBCV. Therefore, we sought to systematically review and determine the effect of ExT on RBCV in healthy individuals across all ages. We conducted a systematic search of MEDLINE, Scopus, and Web of Science, since their inceptions until February 2016 for articles assessing the effect of ExT interventions (not including hypoxic training) on blood volumes in healthy individuals. A meta-analysis was performed to determine the mean difference (MD) in RBCV between post- and pre-ExT measurements. Thirty studies were included after systematic review, comprising a total of 299 healthy individuals (mean age = 19-71 years, 271 males). Exercise training programs primarily consisted in lower limb endurance training interventions (mean duration = 15.2 weeks). After data pooling, RBCV was not increased following ExT (MD = 49 mL, 95% CI = -11, 108; P = 0.11). In subgroup analyses, RBCV was increased after ExT in young and middle-aged individuals (mean age <60 year) (n = 106, MD = 81 mL, 95% CI = 0, 162; P < 0.05) but not in older study participants (mean age ≥60 year) (n = 110, MD = 13 mL, 95% CI = -76, 102; P = 0.77). Heterogeneity was not detected among studies in young and middle-aged (I = 0%) and older individuals (I = 0%). In conclusion, RBCV is moderately, yet consistently, enhanced by ExT in young and middle-aged but not in older healthy individuals. Therefore, RBCV adaptations to ExT appear to be age dependent.

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Flow-Mediated Dilation in Athletes

Abstract: The current meta-analysis provides evidence that master athletes but not young athletes exhibit greater FMD compared with that in age-matched healthy controls, thus suggesting that the association between high levels of exercise training and increased FMD is age dependent.

Cited by 46 publications

References 58 publications

Effect of Regular Aerobic Activity in Young Healthy Athletes on Profile of Endothelial Function and Platelet Activity

Effect of Regular Aerobic Activity in Young Healthy Athletes on Profile of Endothelial Function and Platelet Activity

Plasma asymmetric dimethylarginine concentrations are not related to differences in maximal oxygen uptake in endurance trained and untrained men

Red cell volume response to exercise training: Association with aging

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