Flow-mediated dilatation (FMD) and prevalence of cardiovascular risk factors: the value of FMD assessment in high risk patients is limited

Mizia-Stec, Katarzyna; Wieczorek, Joanna; Orszulak, Michał; Mizia, Magdalena; Gieszczyk-Strózik, Klaudia; Sikora-Puz, A.; Haberka, Maciej; Lasota, Bartosz; Chmiel, Artur

doi:10.5603/kp.a2013.0316

Cited by 5 publications

(4 citation statements)

References 36 publications

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“…The metabolic profile of the analysed group was not optimal, which, unfortunately, is quite common in the CAH population [14]. The question of whether optimal hormonal status of CAH patients improves endothelial function, which is sensitive to minor homeostasis disturbances, remains unanswered [32].…”

Section: Discussionmentioning

confidence: 96%

Vascular and cardiac function in young adults with classical congenital adrenal hyperplasia

Wierzbicka-Chmiel¹,

Chmiel²,

Kajdaniuk³

et al. 2015

EJEA

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Introduction: Patients with classical congenital adrenal hyperplasia (CAH) have increased cardiovascular risk, but the vascular and cardiac function during longitudinal corticoids replacement therapy is not known thoroughly. Material and methods: Cross-sectional study of 19 Caucasian adults with CAH (age 23.7 ± 3.8 years; twelve males) compared to 20 healthy volunteers matched for origin, sex, age, and body mass index (BMI). All of the participants were assessed for flow mediated dilatation of the brachial artery (FMD), intima-media thickness of the common carotid artery (cIMT) and common femoral artery (fIMT), standard echocardiography, and global longitudinal left ventricular function using two-dimensional speckle-tracking echocardiography (LSTE). Results: The patients with CAH, compared with controls, had decreased FMD (9.4 ± 3.9 vs. 19.8 ± 5.2; p < 0.01), and the difference was still significant after correction for potential confounders. cIMT and fIMT were higher in the CAH group at baseline (for cIMT 0.47 ± 0.4 mm vs. 0.40 ± 0.03 mm; p < 0.01, for fIMT 0.47 ± 0.05 mm vs. 0.41 ± 0.04 mm; p < 0.01) but not after correction for potential confounders. The CAH subjects, compared with controls, had normal or similar left ventricular (LV) ejection fraction and LV mass index. The mean absolute value of LSTE differed in the CAH patients compared with controls (-20.5% ± 1.2 vs.-22.5% ± 1.7; p < 0.01), but it was still within the normal range. Conclusions: Young adults with CAH and glucocorticoid long-lasting treatment had impaired FMD, an insignificant increase of IMT, and subclinical changes in LV diastolic function in echocardiography.

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Section: Discussionmentioning

confidence: 96%

Vascular and cardiac function in young adults with classical congenital adrenal hyperplasia

Wierzbicka-Chmiel¹,

Chmiel²,

Kajdaniuk³

et al. 2015

EJEA

Self Cite

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“…No statistically significant difference was detected in subjects with number of risk factors for the value of FMD. Mizia-Stec K et al 25 reported FMD was related only in low risk subjects and no correlation was found in patients with more number of risk factors. Similar findings were noted by Witte DR 26 .…”

Section: Discussionmentioning

confidence: 94%

Correlation of endothelial dysfunction measured by flow-mediated vasodilatation to severity of coronary artery disease

Sancheti¹,

Shah²,

Phalgune³

2018

Indian Heart Journal

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Objectives Brachial artery ultrasound imaging during reactive hyperemia is widely used tool for quantifying endothelium dependent vasomotion. Angiodefender device is used for non invasive determination of percentage flow mediated vasodilation (FMD). An attempt is made to study whether endothelial dysfunction determined by FMD of brachial artery predicts the presence or absence of coronary artery disease and its correlation with the severity of coronary artery disease. Methods One hundred six patients admitted between May 2014 and April 2015 who were posted for coronary angiography diagnosed to have chronic stable angina on clinical basis and/or by exercise stress test, for evaluation of coronary artery disease were submitted to standard clinical evaluation, calculation of percentage FMD by Angiodefender device. Statistical significance of difference of categorical variables was tested using Fisher’s exact test. Sensitivity, specificity, positive predictive value and negative predictive value of FMD were studied. Results There was no correlation between number of risk factors and percentage of FMD. Significantly higher proportion of cases with less FMD had higher prevalence of coronary artery disease and vice-versa. Significantly higher proportion of cases with positive stress test had less percentage of FMD and vice-versa. Significantly higher proportion of cases with less percentage of FMD and positive stress test had higher prevalence of obstructive coronary artery disease and vice-versa. Specificity was 100% when percentage of FMD was ≤10. Conclusions FMD an inexpensive and non-invasive test provides information regarding extent and severity of coronary artery disease.

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“…Endothelial dysfunction leads to vascular disease which has been considered as a primary characteristic in the development of atherosclerosis and an independent predictor of poor prognosis in CVD (Cai and Harrison, 2000; Suwaidi et al , 2000). Endothelium-dependent vascular function is assessed by brachial flow-mediated dilation (FMD) and is inversely associated with the future CVD events (Ras et al , 2013; Jambrik et al , 2004; Mizia-Stec et al , 2014).…”

Section: Introductionmentioning

confidence: 99%

Resveratrol supplementation and flow-mediated dilation: a systematic review

Emamat

Djafarian

Tangestani

et al. 2019

NFS

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Purpose This study aims to systematically review randomized clinical trials (RCTs) evaluated the effects of resveratrol on vascular flow-mediated dilation (FMD). Design/methodology/approach All published RCTs in English were systematically searched on PubMed and Scopus search engines up to October 2017. A total of 61 studies were found through search databases. The outcome variable of interest was FMD. Six articles which met inclusion criteria were included in this study. Findings From six studies, four showed a significant improvement in FMD after resveratrol supplementation acutely or chronically in subjects with cardio-metabolic risk factors. Two other studies did not show any significant effect of resveratrol on FMD. Originality/value The authors systematically reviewed the effectiveness of resveratrol supplementation on FMD for the first time. The findings suggest that pure resveratrol supplementation may have beneficial effects on endothelium dependent vasodilatation indicator, FMD.

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Flow-mediated dilatation (FMD) and prevalence of cardiovascular risk factors: the value of FMD assessment in high risk patients is limited

Abstract: FMD is related to the number of traditional CVRF/CVDs; however, coronary artery disease has the most significant influence on FMD decrease among analysed factors. The value of FMD assessment in high risk patients is limited.

Cited by 5 publications

References 36 publications

Vascular and cardiac function in young adults with classical congenital adrenal hyperplasia

Vascular and cardiac function in young adults with classical congenital adrenal hyperplasia

Correlation of endothelial dysfunction measured by flow-mediated vasodilatation to severity of coronary artery disease

Resveratrol supplementation and flow-mediated dilation: a systematic review

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