Flow Mediated Dilatation and Cardiac Function in Type 1 Diabetes Mellitus

Shivalkar, Bharati; D'hondt, D.; Goovaerts, Inge; Gaal, Luc Van; Bartunek, J.; Crombrugge, Paul Van; Vrints, Christiaan J.

doi:10.1016/j.amjcard.2005.07.111

Cited by 97 publications

(89 citation statements)

References 8 publications

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“…However, majority of these studies were conducted with adult patients in late stages. 20,21 In this study, we found ED in paediatric patients with diabetes. Additionally, ED and AS correlated with diastolic dysfunction.…”

Section: Discussionmentioning

confidence: 59%

Investigation of endothelial dysfunction and arterial stiffness in children with type 1 diabetes mellitus and the association with diastolic dysfunction

Çiftel

Ertuğ

Parlak

et al. 2013

Diabetes and Vascular Disease Research

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Objective: The objective of this study is to investigate endothelial dysfunction (ED) and arterial stiffness (AS) and determine the association with diastolic dysfunction in children with type 1 diabetes mellitus (DM). Methods: A total of 42 patients without diabetic complications (mean age: 13.21 years) and 40 healthy (mean age: 13.07 years) children were included in this study. AS was assessed with ascending aorta M-mode measurements, diastolic dysfunction with pulsed wave (PW) Doppler and tissue Doppler echocardiography measurements and flow-mediated dilatation (FMD) and carotid intima-media thickness (CIMT) with high-resolution ultrasonography. Results: Results of diabetic group and healthy children were compared. In diabetic group, aortic strain (8.40 ± 2.98, 20.12 ± 5.04; p < 0.001), aortic distensibility (7.36 ± 2.92, 16.59 ± 4.25; p < 0.001) and FMD% (7.70 ± 2.83, 11.33 ± 2.85; p < 0.001) were found decreased, and CIMT (0.52 ± 0.09 mm, 0.47 ± 0.08 mm; p < 0.05) was found increased. Additionally, left ventricular lateral segment and right ventricular free-wall isovolumic relaxation time (IVRT) and myocardial performance index (MPI) were found increased. Correlation analyses demonstrated a negative correlation between FMD and IVRT and MPI. Conclusions: ED and AS were found in type 1 DM patients without diabetic complications. Additionally, correlation was shown between increased AS and ED and right and left ventricular diastolic dysfunctions.

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Section: Discussionmentioning

confidence: 59%

Investigation of endothelial dysfunction and arterial stiffness in children with type 1 diabetes mellitus and the association with diastolic dysfunction

Çiftel

Ertuğ

Parlak

et al. 2013

Diabetes and Vascular Disease Research

View full text Add to dashboard Cite

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“…16,39,[126][127][128][129][130][131][132] The extent of atherosclerosis by intravascular ultrasound also correlated with HbA 1c over 18 years of follow-up in the Oslo Study; a 1% increase in mean HbA 1c was associated with a 6.4% increase in coronary vessel stenosis. 78 Intensive DM therapy has been shown to prevent the increase in resting heart rate characteristic of patients with T1DM, 133 and autonomic function was significantly better in patients with intensive DM management.…”

Section: Glycemic Controlmentioning

confidence: 91%

Type 1 Diabetes Mellitus and Cardiovascular Disease

Ferranti¹,

Boer²,

Fonseca³

et al. 2014

Circulation

296

126

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“…Chlumsky et al (33) stated that decompensation (lack of glycemic control) in diabetic patients without late complications leads to deterioration of diastolic function of the left ventricle, which is reversible if compensation with glycemic control occurs early. Shivalkar et al (34) presented data showed an increasing occurrence of subclinical cardiac dysfunction and cardiovascular risk markers with duration in type I diabetic patients compared with age-matched controls. Similarly, Chrapko et al (35) in a gated single positron emission tomography study in asymptomatic type 1 DM patients showed that four years after the basal study there is an increase of left ventricular dimensions and volumes.…”

Section: Discussionmentioning

confidence: 99%

Effect of glycemic control on the progress of left ventricular hypertrophy and diastolic dysfunction in children with type I diabetes mellitus

Dayem¹,

Battah²

2012

Anadolu Kardiyol Derg

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Objective: To evaluate progression of left ventricular (LV) structural and functional changes in patients with type 1 diabetes and effect of glycemic control on these changes. Methods: A prospective, longitudinal study consisted of 48 patients who were originally studied. At two years follow-up, 44 patients were reevaluated, 35 patients from the original study were reevaluated after another 2 years for the 3 rd time using the same protocol. The control group comprised 30 age-and sex-matched healthy volunteers. All studied patients were subjected to full history taking, clinical and cardiac examination. M-mode echocardiography was done, blood samples were taken and examined for HbA1c and urine samples were tested for the presence of albuminuria. ANOVA for repeated measurements, t-test for dependent and independent variables, and Mann-Whitney U test were used for statistical analyses. Results: Seven (14.6%) of our patients had LV hypertrophy, 23 (47.9%) patients had diastolic dysfunction and ten patients only achieve improvement in glycemic control. Duration of diabetes was significantly higher in patients with LV hypertrophy (LVH) (p<0.05). Patients with no improvement in glycemic control had a significant increase in interventricular septum (IVS) and left ventricular posterior wall (LVPW) in the third examination (p<0.05 for both). Conclusion: Prevalence of LVH and diastolic dysfunction among diabetic patients is high. Glycemic control in diabetic patients could not improve LVH or diastolic dysfunction. On the other hand, failure to achieve glycemic control leads to deterioration in structural parameters. (Anadolu Kardiyol Derg 2012; 12: 498-507) Key words: Glycemic control, echocardiography, progression, insulin-dependent diabetes mellitus, left ventricular hypertrophy, diastolic dysfunction Original Investigation Özgün Araşt›rma 498ÖZET Amaç: Diyabetik hastalarda sol ventrikülün yapısal ve işlevsel değişikliklerinin ilerlemesi ve tip 1 diyabetin etkisi ile bu değişikliklere glisemik kontrolün etkisini değerlendirmek. Yöntemler: Bu prospektif, longitüdinal çalışma başlangıçta 48 hastadan oluşmaktaydı. İki yıllık takip sırasında, 44 hasta tekrar değerlendirildi, orijinal çalışmadan 35 hasta sonraki 2 yılda aynı protokoller kullanılarak tekrar değerlendirildi. Kontrol grubu cinsiyet ve yaş uyumlu 30 sağlıklı gönüllüden oluşmaktaydı. Çalışılan tüm hastalar, tam öyküleri alınıp, klinik ve kardiyak incelemeye tabi tutuldu. M-mode ekokardiyografi yapıldı, kan örnekleri alındı, HbA1c için değerlendirildi ve idrar örnekleri albüminüri varlığı için test edildi. İstatiksel analizde, tekrarlayan ölçümler için ANOVA, bağımlı-bağımsız değişkenler için t-test ve Mann-Whitney U testi kullanıldı. Bulgular: Hastalarımızın 7'sinde (%14.6) sol ventrikül hipertrofisi (SVH) vardı, 23 (%47.9) hasta da diyastolik disfonksiyon vardı ve yalnızca 10 hastada glisemik kontrolde iyileşme sağlandı. Diyabet süresi SVH olan hastalarda önemli derecede daha yüksekti (p<0.05). Glisemik kontrolde iyileşme olmayan hastaların üçüncü kontrol...

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Flow Mediated Dilatation and Cardiac Function in Type 1 Diabetes Mellitus

Cited by 97 publications

References 8 publications

Investigation of endothelial dysfunction and arterial stiffness in children with type 1 diabetes mellitus and the association with diastolic dysfunction

Investigation of endothelial dysfunction and arterial stiffness in children with type 1 diabetes mellitus and the association with diastolic dysfunction

Type 1 Diabetes Mellitus and Cardiovascular Disease

Effect of glycemic control on the progress of left ventricular hypertrophy and diastolic dysfunction in children with type I diabetes mellitus

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