Flow Injection Post-Chemiluminescence Reaction of Astemizole in N-Bromosuccinimide-Calcein System and Its Application

Fang, Zhao

doi:10.1080/00032719.2012.689904

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…When lercanidipine was injected into the reaction mixture of N ‐chlorosuccinimide and eosin Y, it was oxidized with an excess of N ‐chlorosuccinimide and released energy. The product of oxidation at the ground state received this energy and was again excited, accompanied by CL .…”

Section: Resultsmentioning

confidence: 99%

Flow injection chemiluminescence determination of lercanidipine based on N‐chlorosuccinimide–eosin Y post‐chemiluminescence reaction

2014

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A novel post-chemiluminescence (PCL) reaction was discovered when lercanidipine was injected into the CL reaction mixture of N-chlorosuccinimide with alkaline eosin Y in the presence of cetyltrimethylammonium bromide (CTAB), where eosin Y was used as the CL reagent and CTAB as the surfactant. Based on this observation, a simple and highly sensitive PCL method combined with a flow injection (FI) technique was developed for the assay of lercanidipine. Under optimum conditions, the CL signal was linearly related to the concentration of lercanidipine in the range 7.0 × 10(-10) to 3.0 × 10(-6) g/mL with a detection limit of 2.3 × 10(-10) g/mL (3σ). The relative standard deviation (RSD) was 2.1% for 1.0 × 10(-8) g/mL lercanidipine (n = 13). The proposed method had been applied to the estimation of lercanidipine in tablets and human serum samples with satisfactory results. The possible CL mechanism is also discussed briefly.

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Section: Resultsmentioning

confidence: 99%

Flow injection chemiluminescence determination of lercanidipine based on N‐chlorosuccinimide–eosin Y post‐chemiluminescence reaction

2014

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“…Coupled with flow injection (FI) techniques, FI–CL analysis has the advantage of being rapid, sensitive and economical, with a wide linear range, and has been applied in various fields, especially in pharmaceutical analysis. Recently, several reports have described the application of FI–CL analysis to different formulations such as powder‐injection , tablet , injection and capsule . Combined with pretreatment technology, several FI–CL methods had been developed to detect drugs in biological samples .…”

Section: Introductionmentioning

confidence: 99%

Flow‐injection chemiluminescence method to detect a β₂ adrenergic agonist

et al. 2014

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A new method for the detection of β2 adrenergic agonists was developed based on the chemiluminescence (CL) reaction of β2 adrenergic agonist with potassium ferricyanide-luminol CL. The effect of β2 adrenergic agonists including isoprenaline hydrochloride, salbutamol sulfate, terbutaline sulfate and ractopamine on the CL intensity of potassium ferricyanide-luminol was discovered. Detection of the β2 adrenergic agonist was carried out in a flow system. Using uniform design experimentation, the influence factors of CL were optimized. The optimal experimental conditions were 1 mmol/L of potassium ferricyanide, 10 µmol/L of luminol, 1.2 mmol/L of sodium hydroxide, a flow speed of 2.6 mL/min and a distance of 1.2 cm from 'Y2 ' to the flow cell. The linear ranges and limit of detection were 10-100 and 5 ng/mL for isoprenaline hydrochloride, 20-100 and 5 ng/mL for salbutamol sulfate, 8-200 and 1 ng/mL for terbutaline sulfate, 20-100 and 4 ng/mL for ractopamine, respectively. The proposed method allowed 200 injections/h with excellent repeatability and precision. It was successfully applied to the determination of three β2 adrenergic agonists in commercial pharmaceutical formulations with recoveries in the range of 96.8-98.5%. The possible CL reaction mechanism of potassium ferricyanide-luminol-β2 adrenergic agonist was discussed from the UV/vis spectra.

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Potassium Periodate–Luminol–Silver Nanoparticles as a New Chemiluminescence System and its Application to Detect Fenoterol and Orciprenaline

Wang

et al. 2014

Analytical Letters

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Flow Injection Post-Chemiluminescence Reaction of Astemizole in N-Bromosuccinimide-Calcein System and Its Application

Cited by 3 publications

References 24 publications

Flow injection chemiluminescence determination of lercanidipine based on N‐chlorosuccinimide–eosin Y post‐chemiluminescence reaction

Flow injection chemiluminescence determination of lercanidipine based on N‐chlorosuccinimide–eosin Y post‐chemiluminescence reaction

Flow‐injection chemiluminescence method to detect a β₂ adrenergic agonist

Potassium Periodate–Luminol–Silver Nanoparticles as a New Chemiluminescence System and its Application to Detect Fenoterol and Orciprenaline

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Flow Injection Post-Chemiluminescence Reaction of Astemizole in N-Bromosuccinimide-Calcein System and Its Application

Cited by 3 publications

References 24 publications

Flow injection chemiluminescence determination of lercanidipine based on N‐chlorosuccinimide–eosin Y post‐chemiluminescence reaction

Flow injection chemiluminescence determination of lercanidipine based on N‐chlorosuccinimide–eosin Y post‐chemiluminescence reaction

Flow‐injection chemiluminescence method to detect a β2 adrenergic agonist

Potassium Periodate–Luminol–Silver Nanoparticles as a New Chemiluminescence System and its Application to Detect Fenoterol and Orciprenaline

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Product

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Flow‐injection chemiluminescence method to detect a β₂ adrenergic agonist