Flow Injection Analysis-Based Electrochemiluminescence: An Overview of Experimental Design and Its Biosensing Applications

Abstract

Over the past few decades, electrochemiluminescence (ECL) has been used as a powerful analytical tool for in vitro diagnosis due to its promising potential in light-emitting devices, which has greatly promoted recent electrochemical studies. Plenty of research articles on the ECL technique have been published by various researchers around the globe. On the other hand, studies on the coupling of ECL sensing strategies with other techniques are recently getting widespread attention. ECL strategies have been effectively coupled with scanning electrochemical microscope, flow injection analysis (FIA), and capillary electrophoresis. These coupled techniques have been effectively employed for various health care applications. Among these techniques, FIA coupled ECL sensing strategies have been designated as the most emerging technique, especially sensing of clinical samples. This critical review discusses the vibrant developments in FIA-ECL, the mechanism of ECL, the design of FIA-ECL, and highlights the application of FIA-ECL for the detection of immunoassays, catecholamines, antioxidant compounds, choline, tetracyclines, and pharmaceutical drugs. The current review will pave the way for the design and development of FIA-ECL for efficient point- of-care applications.

Partly-O-Diamond Solution-Gate Field-Effect Transistor as an Efficient Biosensor of Glucose

“…3 Recently, biosensing technology has been playing an important role in detecting biological agents for diagnosis of life-threatening diseases. [4][5][6][7][8][9][10][11][12] Due to the outstanding properties of carbon materials, many biosensors have introduced graphene, 13 carbon nanotubes, 14 graphene oxide 15 for glucose monitoring. 16 As for graphene, high specific surface is beneficial for the immobilization of glucose oxidase (GOD), 17 but simultaneously more contaminants are adsorbed on surface.…”

Machine-Learning-Assisted Blood Parameter Sensing Platform for Rapid Next Generation Biomedical and Healthcare Applications

“…6 Detecting albumin levels in blood serum is important for diagnosing various medical conditions, such as kidney disease, liver disease, and nutritional deficiencies. The existing methods of albumin detection are based on Colorimetric Assays, Immunological Assays, Electrophoresis, High-Performance Liquid Chromatography (HPLC), Optical method, Fluorescence, Electrochemical, and Biosensor methods [7][8][9][10][11][12][13][14][15] Colorimetric assays are widely used for albumin detection. It uses bromocresol green dye, which binds to albumin and changes color based on the amount of albumin present in the test sample.…”

Green Synthesis of Copper Oxide Nanoparticle Decorated Polypyrrole-Chitosan on Pencil Graphite Electrode for Enzyme-Free Glucose Sensors

“…Electrode materials using nanoparticles have been used in many fields in recent years. For example; biochemistry, 1,2 drug analysis, [3][4][5] biosensor applications, 6,7 health monitoring with wearable sensors, 8 scientific diagnostics and analysis, 9,10 environmental monitoring, and food safety. 11,12 Among the reasons for the use of nanoparticles, besides their very superior physicochemical properties, these materials have the surface area and volume ratios, they can provide the necessary and appropriate sensitivity due to their strong adsorption and analyte properties, 13,14 allowing them to be used alone or in combination with different conductive materials.…”