Flow induces common and specific transcriptional changes in renal tubular epithelial cells involving the PI3K pathway
Kevin Tröndle,
Ludovica Rizzo,
Roman Pichler
et al.
Abstract:Flow‐induced shear stress affects renal epithelial cells in the nephron tubule with potential implications for differential functionalities of the individual segments. Disruptions of cellular mechanosensation or flow conditions are associated with the development and progression of various renal diseases. This study investigates the effects of flow on the transcriptome of various renal tubular epithelial cell types. We analyzed the transcriptome of induced renal epithelial cells (iREC) cultured under physiolog… Show more
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