“…We show the effect of slip length on the shear flow past a two-dimensional capsule and simulate the compression of an elastic membrane lying on a viscous fluid substrate.Another approach developed to study fluid/interface interaction within the creeping flow regime is the boundary integral method, where only the surface of the interface needs to be discretized. The method is very successful at simulating drops in viscous flows [18,19] and was extended to elastic interfaces by projecting the velocity gradient of the surrounding fluid to find the deformation rate of the interface [20,21].Most of these methods, however, have in common a Lagrangian mesh for the structure interacting with the fluid and cannot easily handle the large deformations or viscoelastic behaviors observed in many biological systems. Indeed, when the membrane is described in a Lagrangian framework, extreme deformations often lead to severe distortions of the finite element mesh, an issue that can only be approached by complicated and computationally expensive mesh regularization techniques [22].A solution to this problem was presented by Cottet et al in [23] via the introduction of a fully Eulerian description of the system, in which kinematic quantities representing the interface motion (such as position or dilation) are implicitly described by a level-set function, which is defined and updated on a fixed underlying Eulerian grid.…”