Flow-induced corrosion behavior of absorbable magnesium-based stents

Wang, Juan; Giridharan, Venkataraman; Shanov, Vesselin; Xu, Zhigang; Collins, Boyce; White, Leon; Jang, Yong-Seok; Sankar, Jagannathan; Huang, Nan; Yun, Yeoheung

doi:10.1016/j.actbio.2014.08.034

Cited by 117 publications

(97 citation statements)

References 33 publications

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“…This result is in conflict with the authors' previous work, however it is believed this disparity in an artefact of flow conditions [36]. The samples in Wang et al [60] were studied as stent materials and as such were placed directly in the pipe, in order to better mimic services conditions. The solution flow in the authors' previous study [36] was spread across the 6 samples in a large body of solution (~3 L).…”

Section: Solution Flow Ratecontrasting

confidence: 55%

“…However, in addition to an increase in general corrosion, Wang et al [60] also discovered a higher incidence of localised corrosion at high flow rates. This result is in conflict with the authors' previous work, however it is believed this disparity in an artefact of flow conditions [36].…”

Section: Solution Flow Ratementioning

confidence: 99%

“…Maybe the most detailed analysis of solution flow on Mg corrosion was conducted by Wang et al [60]. In this study Mg-5Zn-0.3Ca plates were studied under a number of flow conditions, and AZ31 stents in stagnant conditions were compared to those under solution flow.…”

Section: Solution Flow Ratementioning

confidence: 99%

“…Wang et al [60] tabulated a range of mean wall shear stresses associated with various cardiovascular sites and these are presented in Table 7 [60]. Values such as these should be combined with a shear stress (τ) calculation such as Doriot's equation [116], presented in Equation (4), to better approximate in vivo service conditions.…”

Section: Solution Flow Ratementioning

confidence: 99%

“…Many studies also conduct an analysis of the corrosion products and the layers these products form on the sample's surface (also known as surface films) [60]. More stable corrosion products or oxide/hydroxide films forming on the surface of the sample reduce the sample's active contact area with the solution, thereby providing some protection from corrosion.…”

Section: Magnesium Corrosion Assessmentmentioning

confidence: 99%

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Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

2017

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The factors that influence magnesium (Mg) corrosion in vitro are systematically evaluated from a review of the relevant literature. We analysed the influence of the following factors on Mg biocorrosion in vitro: (i) inorganic ions, including both anions and cations, (ii) organic components such as proteins, amino acids and vitamins, and (iii) experimental parameters such as temperature, pH, buffer system and flow rate. Considerations and recommendations towards a standardised approach to in vitro biocorrosion testing are given. Several potential simulated body fluids are recommended. Implementing a standardised approach to experimental parameters has the potential to significantly reduce variability between in vitro biocorrosion tests, and to help build towards a methodology that accurately and consistently mimics in vivo corrosion. However, there are also knowledge gaps with regard to how best to characterise the in vivo environment and corrosion mechanism. The assumption that blood plasma is the correct bodily fluid upon which to base in vitro methodologies is examined, and factors that influence the corrosion mechanism in vivo, such as specimen encapsulation, bear consideration for further studies.

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Section: Solution Flow Ratecontrasting

confidence: 55%

Section: Solution Flow Ratementioning

confidence: 99%

Section: Solution Flow Ratementioning

confidence: 99%

Section: Solution Flow Ratementioning

confidence: 99%

Section: Magnesium Corrosion Assessmentmentioning

confidence: 99%

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Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

2017

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Flow Induced Biodegradation Behavior of Magnesium Metal: From Bioreactors to in Vivo Models

Wang¹,

Huang²,

Yun³

et al. 2016

Magnesium Technology 2016

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Dynamic Corrosion and Material Characteristics of Mg–Zn–Zr Mini‐Tubes: The Influence of Microstructures and Extrusion Parameters

et al. 2017

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In this study, magnesium-zinc-zirconium (Mg-Zn-Zr) alloy mini-tubes that fit the diameter of cardiovascular stents are successfully fabricated using an isothermal extrusion method. The influence of extrusion temperature and ram speed on the microstructure are examined. In addition, this research develops a novel dynamic-corrosion apparatus for Mg alloy mini-tube examination, and supplemented with electrochemical, and biocompatibility tests, the optimal criteria for mini-tube extrusion are defined. The optimized specimen not only retains a homogeneous fine-grained structure with a grain size of about 2 mm, but also possesses 300 MPa yielding strength and nearly 15% elongation. Compared with a coarse-grained microstructure, the finegrained specimens significantly reduces the corrosion and oxidation rates in a dynamic-flow field, resulting in favorable characteristics of degradation, cytocompatibility, and hemocompatibility. The results suggest that precisely controlling the extrusion process can improve the mechanical properties as well as the biocompatibility of Mg alloys for application in cardiovascular implants.

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Flow-induced corrosion behavior of absorbable magnesium-based stents

Cited by 117 publications

References 33 publications

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

Flow Induced Biodegradation Behavior of Magnesium Metal: From Bioreactors to in Vivo Models

Dynamic Corrosion and Material Characteristics of Mg–Zn–Zr Mini‐Tubes: The Influence of Microstructures and Extrusion Parameters

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