Flow-driven competition between two capsules passing through a narrow pore

Li, Yingxiang; Xing, Bao-Hua; Ding, Mingming; Shi, Tongfei; Sun, Zhao-Yan

doi:10.1039/d1sm01271a

Soft Matter

2021

DOI: 10.1039/d1sm01271a

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Flow-driven competition between two capsules passing through a narrow pore

Yingxiang Li

Bao-Hua Xing²,

Mingming Ding

et al.

Abstract: By incorporating a distance function into finite element simulation, we investigate the flow-driven competition between two soft capsules passing through a narrow pore, employing the arbitrary Lagrangian-Eulerian formulation to satisfy...

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Cited by 4 publications

References 52 publications

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Dynamic behaviors of capsules on rough surfaces induced by shear flow under gravity

Zhang

Duan

et al. 2022

Physics of Fluids

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We use a finite element method to investigate dynamic behaviors of capsules on rough surfaces induced by shear flow under gravity, which has a more practical significance for related applications such as medical implants. Our model is set as a neutral rough surface, which does not have the adhesive bonds normally assumed by micro-molecular simulations. Our results demonstrate that the capsule exhibits three motion modes: adhesion, slip, and detachment mainly depending on the shear rate, which are similar to the phenomena in which adhesive bonds (linear spring) are assumed between capsules and a smooth surface. At low shear rates, the capsule was slightly deformed, and its bottom in contact with the rough surface, hence, promotes adhesion. However, it is surprising to find that, at relatively high shear rates, the effect of capsule deformability on its adhesion dynamics is far more complex than just promoting adhesion. High deformability of the capsule gives it a concave shape at its bottom, thereby no adhesion formation in the middle. The appearance of this specific capsule shape inhibits the adhesion of the capsule but makes the capsule slip. In addition, it is interesting to note that when the shear rate exceeds a critical value, the slip state no longer appears but changes to detachment.

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Dynamic behaviors of capsules on rough surfaces induced by shear flow under gravity

Zhang

Duan

et al. 2022

Physics of Fluids

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Dynamics of Janus vesicles passing through a narrow pore

Li,

Han,

et al. 2023

Physics of Fluids

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Janus vesicles have garnered significant attention due to their versatility and potential applications. Investigating the perforation dynamics of Janus vesicles represents a fundamental physical inquiry in this distinctive structure and helps to understand their promising applications in drug delivery, biomedicine, and others. However, the perforation kinetic behavior of Janus vesicles has yet to be elaborated. Here, we employ the finite element method to explore the dynamics of Janus vesicles passing through a narrow pore in a microchannel. Results demonstrate that Janus vesicles, characterized by their asymmetric membrane structure, have a non-negligible effect on vesicle deformation while crossing the pore. Specifically, the Janus property strengthens membrane deformation on the low modulus side while weakening it on the high modulus side. Additionally, Janus vesicles exhibit an increased perforation speed. Results further determine that the non-axially positioned Janus vesicles experience a bigger rotation angle than uniform modulus vesicles by constructing the rotation angle θ. This research provides valuable insight into the movement and deformation of Janus vesicles during their passage through a pore, which can guide optimization and design of Janus vesicles for drug carriers, catalysis, and more.

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Numerical investigation on flow-induced wall shear stress variation of metastatic cancer cells in lymphatics with elastic valves

Zhang,

Yue,

Zhang

2024

Computer Methods in Biomechanics and Biomedical Engineering

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Flow-driven competition between two capsules passing through a narrow pore

Abstract: By incorporating a distance function into finite element simulation, we investigate the flow-driven competition between two soft capsules passing through a narrow pore, employing the arbitrary Lagrangian-Eulerian formulation to satisfy...

Cited by 4 publications

References 52 publications

Dynamic behaviors of capsules on rough surfaces induced by shear flow under gravity

Dynamic behaviors of capsules on rough surfaces induced by shear flow under gravity

Dynamics of Janus vesicles passing through a narrow pore

Numerical investigation on flow-induced wall shear stress variation of metastatic cancer cells in lymphatics with elastic valves

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