Flow diverters for treatment of intracranial aneurysms: Current status and ongoing clinical trials

Computational Hemodynamics Analysis of Intracranial Aneurysms Treated with Flow Diverters: Correlation with Clinical Outcomes

“…Each Silk FD, regardless of size, is composed of forty 30-nitinol and eight 50-m platinum microfilaments; with pore sizes of 110 -250 . 7,11 For the successful cases, patients 1-4, the aneurysms were completely occluded by 6 months. For the failed cases 5 and 6, persistent residual aneurysms were observed at 6 months.…”

“…The timeframe for complete occlusion of an aneurysm is unknown, but recent series have documented 6-month occlusion rates of 89.0%-93.3%. 7 Of more concern are reports of delayed parenchymal or subarachnoid hemorrhage following FD treatment. These have been estimated to be up to 1.75% for the Pipeline Embolization Device and 0.8% for Silk.…”

“…These have been estimated to be up to 1.75% for the Pipeline Embolization Device and 0.8% for Silk. 7 Hemodynamic factors and aggres-sive thrombus-associated autolysis of the aneurysm wall have been implicated. 8,9 Computational fluid dynamics (CFD) analysis has been applied in the study of the hemodynamics of aneurysm growth and rupture, as well as various types of stents, including FDs.…”

Endovascular Treatment of Internal Carotid and Vertebral Artery Aneurysms Using Covered Stents

“…The primary intent of a flow diversion device (as opposed to a stent) is to optimally alter the flow exchange between the parent artery and the aneurysm so as to promote complete thrombosis of the sac as rapidly as possible while eliciting minimal neointimal hyperplasia. The principal goal of the flow divertor is placement in the parent artery in order to reconstruct the vessel wall [37]. The concept of flow diversion appears promising in challenging lesions, including fusiform and/or giant aneurysms.…”

Numerical simulation of RF catheter ablation for the treatment of arterial aneurysm

“…Interventional cardiovascular catheterization, such as stent and coiling are both of the advances to treat aneurysms [6][7][8], should stay in the body and have some complications, such as the displacement of the stent and the coil fall off from the aneurysm [9,10]. Considering the blood coagulation induced by the heating of radiofrequency ablation (RFA), the mechanism of aneurysm embolization and the advantages of simple operation, small trauma, low cost, faster recovery, high success rate, etc [11][12][13][14][15] , Qiao, et al proposed that RFA may be used to treat aneurysm by combining the mechanism of blood coagulation of RFA and aneurysm embolization [16].…”