Flow-cytophotometric studies in renal carcinoma

Schwabe, Holger; Adophs, H. D.; Vogel, Jürgen

doi:10.1007/bf00257716

Cited by 25 publications

(12 citation statements)

References 14 publications

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“…Ljungberg's data were supported by other groups [20], though some authors [21][22][23] did not find any correlation between DNA content and the biological behavior of the tumor. For instance, Currin et al [22] describe the pro gression rate in patients with diploid renal cell carcinoma.…”

Section: Discussionsupporting

confidence: 77%

DNA Content and the Proliferation Marker Ki-67 as Prognostic Indicators in Renal Cell Carcinoma

Papadopoulos

Weichert-Jacobsen²,

Sprenger³

et al. 1994

Urol Int

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Patients suffering from renal cell carcinoma have a generally poor prognosis. Even cases that are clinically in comparable stages can, however, take quite different courses. The basic prognostic factors, histological grade and TNM stage do not do justice to the heterogeneous biological behavior of this tumor entity. In this study, the possible prognostic indicators, DNA content and proliferation rate, assessed with Ki-67, were compared with the histological grade and the TNM stage. Though there was no correlation between the proliferation rate (Ki-67) and the two, there was a significant correlation between DNA content and both histological grade and TNM stage.

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Section: Discussionsupporting

confidence: 77%

DNA Content and the Proliferation Marker Ki-67 as Prognostic Indicators in Renal Cell Carcinoma

Papadopoulos

Weichert-Jacobsen²,

Sprenger³

et al. 1994

Urol Int

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“…By combin ing pathologic tumor grading and flow cytometry addi tional prognostic information was obtained [10] and a malignancy index which discriminated patient sub groups with different prognoses was defined [124]. Con trary to the above data, however, other studies failed to demonstrate clear survival advantages for patients with diploid tumors when controlled for tumor stage [125][126][127], Although it is widely agreed that determination of the DNA content has prognostic implications, further studies seem necessary to prove whether it contributes significant prognostic information independent of tumor stage and grade.…”

Section: Dna Cytometry (Static Cytophotometry and Flow Cytometry)mentioning

confidence: 99%

Classic and Modern Prognostic Indicators in Renal Cell Carcinoma

Strohmeyer¹,

Ackermann²

1991

Urol Int

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The value of classic and modern prognostic factors in renal cell carcinoma as reported in the literature is determined in a review. Tumor stage is the most important single independent prognostic factor. The presence or absence of distant metastases is highly prognostic and presence of lymph node metastases is of higher prognostic value than the presence of renal vein invasion. For each given tumor stage tumor grade (especially nuclear grade) is the most reliable additional independent prognostic factor predicting patient survival. The significance of DNA cytometry as an independent prognostic factor is less clear, though it might be useful in combination with nuclear grading. Patient-related potential prognostic factors such as age, sex and serologic parameters are of lesser, if any, importance. In the future, data from molecular analysis on oncogenes and suppressor genes are likely to provide additional prognostic information.

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“…Recent studies have attempted to determine the prog nostic value of DNA ploidy [6,[22][23][24][25][26][27], The results regard ing correlation of DNA content with survival time and other prognostic parameters such as local tumor stage and tumor grade were inconsistent, so that a definite answer on the prognostic relevance of DNA ploidy has not yet been found. Some of these discrepanices can be explained by the heterogeneity of renal cell tumors.…”

Section: Dnamentioning

confidence: 99%