Flow cytometry assay of myeloid dendritic cells (mDCs) in peripheral blood during acute hepatitis C: Possible pathogenetic mechanisms

Perrella, Alessandro; Atripaldi, Luigi; Bellopede, Pasquale; Patarino, Tommaso; Sbreglia, Costanza; Tarantino, Giovanni; Sorrentino, Paolo; Conca, Paolo; Ruggiero, Luca; Perrella, Oreste

doi:10.3748/wjg.v12.i7.1105

Cited by 13 publications

(13 citation statements)

References 17 publications

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“…The MDC function, judged by cytokine production and allostimulatory activity, ranges from normal to impaired in patients who have acute HCV infection [3,[23][24][25]. In addition, patients with acute HCV infection who exhibit low frequency and impaired allostimulatory function of MDCs have a higher chance of developing viral persistence, while an increased numerical prevalence of PDCs in the blood circulation during acute HCV infection could be a predictor of successful viral clearance [24,25].…”

Section: Dendritic Cell Function In Acute Hcv Infectionmentioning

confidence: 99%

“…In addition, patients with acute HCV infection who exhibit low frequency and impaired allostimulatory function of MDCs have a higher chance of developing viral persistence, while an increased numerical prevalence of PDCs in the blood circulation during acute HCV infection could be a predictor of successful viral clearance [24,25].…”

Section: Dendritic Cell Function In Acute Hcv Infectionmentioning

confidence: 99%

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Dendritic cells in hepatitis C infection: can they (help) win the battle?

Dolganiuc

Szabó

2011

J Gastroenterol

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Infection with hepatitis C virus (HCV) is a public health problem; it establishes a chronic course in ~85% of infected patients and increases their risk for developing liver cirrhosis, hepatocellular carcinoma, and significant extrahepatic manifestations. The mechanisms of HCV persistence remain elusive and are largely related to inefficient clearance of the virus by the host immune system. Dendritic cells (DCs) are the most efficient inducers of immune responses; they are capable of triggering productive immunity and maintaining the state of tolerance to self- and non-self antigens. During the past decade, multiple research groups have focused on DCs, in hopes of unraveling an HCV-specific DC signature or DC-dependent mechanisms of antiviral immunity which would lead to a successful HCV elimination strategy. This review incorporates the latest update in the current status of knowledge on the role of DCs in anti-HCV immunity as it relates to several challenging questions: (a) the phenotype and function of diverse DC subsets in HCV-infected patients; (b) the characteristics of non-human HCV infection models from the DCs' point of view; (c) how can in vitro systems, ranging from HCV protein- or peptide-exposed DC to HCV protein-expressing DCs, and in vivo systems, ranging from HCV protein-expressing transgenic mice to HCV-infected non-human primates, be employed to dissect the role of DCs in triggering/maintaining a robust antiviral response; and (d) the prospect of DC-based strategy for managing and finding a cure for HCV infection.

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Section: Dendritic Cell Function In Acute Hcv Infectionmentioning

confidence: 99%

Section: Dendritic Cell Function In Acute Hcv Infectionmentioning

confidence: 99%

Dendritic cells in hepatitis C infection: can they (help) win the battle?

Dolganiuc

Szabó

2011

J Gastroenterol

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“…1 2 Treatment options range from drug therapy, including spasmolytics, steroids, mesalasin, and endoscopic treatment comprising argon plasma coagulation (APC), laser coagulation, and formalin application, to hyperbaric oxygen therapy and finally surgical intervention. [3][4][5] We describe a patient with severe refractory haemorrhagic radiation proctitis requiring frequent blood transfusions who was successfully treated with low dose oral thalidomide.…”

Section: Thalidomide In Refractory Haemorrhagic Radiation Induced Promentioning

confidence: 99%

Elevated CD4+/CD25+ T cell frequency and function during acute hepatitis C presage chronic evolution

Perrella

Vitiello²,

Atripaldi

et al. 2006

Gut

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“…A recent study based on a small group of patients with acute HCV infection indicated that an increase in the frequency of MDCs during acute HCV may be associated with viral clearance, whereas lack of such increase might be an important factor in the development of chronic infection. 90 MDCs of patients with chronic HCV infection have impaired abilities to stimulate allogeneic CD4 T cells and to produce IL-12 p70 compared with those from healthy volunteers. 61,86 After exposure to naïve CD4 T cells, MDCs from patients were less able to drive the T helper type 1 response.…”

Section: Dendritic Cells In Hcv Infectionmentioning

confidence: 96%

Altered innate immunity in chronic hepatitis C infection: Cause or effect?

2007

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H epatitis C virus (HCV) is a uniquely successful hepatitis virus in its ability to establish chronic infection in more than two-thirds of those who contract it. The inability of the innate and adaptive immune responses to control HCV invasion and replication contribute to development and persistence of chronic infection. Multiple components have been identified in this process, including pathways by which HCV subverts innate immune recognition and activation, delayed organization of an effective adaptive immune response, the tolerogenic liver environment, and the persistently high levels of viral antigens. We summarize recent findings on the interaction between HCV infection and innate immune responses. Hepatitis C Virus, Immune Responses and Hepatocytes-Brief OverviewA critical role for innate and adaptive immunity has been identified in HCV persistence and liver injury. During acute infection, type I interferon (IFN) is induced in the liver; however, HCV viral load does not decrease, suggesting that HCV interferes with antiviral mechanisms. Innate immune cells, including natural killer cells and dendritic cells shape innate immunity and determine adaptive immune activation. Vigorous, multi-epitopespecific, T helper 1-type and sustained CD4ϩ and CD8ϩ T cell responses were found in resolved acute HCV infections. [1][2][3][4] In contrast, in cases that progress to chronic infection, CD4ϩ T cell responses are weak, short-lived, and targeted to a narrow range of epitopes. 1

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Flow cytometry assay of myeloid dendritic cells (mDCs) in peripheral blood during acute hepatitis C: Possible pathogenetic mechanisms

Abstract: The lack of increase of mDCs during acute hepatitis C might be an important factor involved in chronicization of the infection.

Cited by 13 publications

References 17 publications

Dendritic cells in hepatitis C infection: can they (help) win the battle?

Dendritic cells in hepatitis C infection: can they (help) win the battle?

Elevated CD4+/CD25+ T cell frequency and function during acute hepatitis C presage chronic evolution

Altered innate immunity in chronic hepatitis C infection: Cause or effect?

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