Flow cytometry as a prognostic predictor in gastric linitis plastica

Abstract

The majority of GLP tumors manifest diploid characteristics, and the presence or absence of lymph node metastasis is a major determinant in overall survival.

Overexpression of Transforming Growth Factor-β1 in Scirrhous Carcinoma of the Stomach Correlates with Decreased Survival

“…ence of epidermal growth factor receptor and prognosis. According to Candel et al [26], DNA content correlated significantly with lymph node status, but not with overall survival in 43 surgically treated patients with gastric linitis plastica. Kuniyasu et al [27] reported that amplification of the c-met gene might play a role in carcinogenesis and progression of gastric cancer, especially scirrhoustype gastric carcinoma.…”

Is there a case for routine clinical application of ploidy measurements in gastrointestinal tumours?

“…In addition, DNA aneuploidy was established as an independent prognostic marker in several studies 109–124 . Other studies failed to show such a correlation between ploidy and patient survival at all 125–132 …”

“…A number of studies demonstrated that DNA aneuploidy is correlated with advanced local tumour extent (pT) 107,119,120,122–124,133 or increased number of lymph node metastases (pN) 102,103,108,109,115,118,120–124,128,131,133,134 . However, other studies failed to prove this association of DNA aneuploidy and tumour progression 101,105,113,117,125,129,130,135 …”