Flow Cytometric Evaluation of the Safety of Intraoperative Salvaged Blood Filtered with Leucocyte Depletion Filter in Spine Tumour Surgery

Are we ready for the use of intraoperative salvaged blood in metastatic spine tumour surgery?

“…However, we could examine whether tumour cells were present or not and their density in the form of the number of tumour cells per high power field (semi-quantitative data). Our quantitative study [26] on IOCS-LDF in removing tumour cells using flow cytometry in 12 consecutive patients showed similar results-the tumour cell count in IOCS-LDF processed was significantly lower than that in blood from patients' circulation at any time.…”

“…We have gone a step further and studied the blood samples from a subset of 12 out of 50 patients using flow cytometry [26]. This can be classed as an advanced cellular evidence study.…”

Metastatic spine tumor surgery: does perioperative blood transfusion influence postoperative complications?

“…Patient blood management is an evidence‐based patient‐tailored approach aimed at reducing the need for ABT by managing anemia, perioperative blood conservation by diminishing blood loss or promoting RBC production, reinfusing patient's own blood (e.g., cell salvage), and/or surgical hemostasis . Transfusion of autologous salvaged blood in MSTS has been recently investigated and advocated to be a viable clinical option for reduction of allogeneic product use during oncologic surgeries …”

“…45 Transfusion of autologous salvaged blood in MSTS has been recently investigated and advocated to be a viable clinical option for reduction of allogeneic product use during oncologic surgeries. [46][47][48][49][50][51]…”

Metastatic efficiency of tumour cells can be impaired by intraoperative cell salvage process: truth or conjecture?

“…Establishing clinical evidence would be the last step, where the salvaged blood is transfused to the patients and outcomes, such as tumour progression, tumour recurrence or survival, are evaluated. In accordance with the aforementioned concept, the previous studies in literature (Connor et al ., ; Park et al ., ; Gray et al ., ; Davis et al ., ; Muscari et al ., ; Nieder et al ., ; Stoffel et al ., ; Nieder et al ., ; Ford et al ., ; Bower et al ., ; Gorin et al ., ; Kim et al ., ) including our own in metastatic spine tumour surgery (Kumar et al ., ,b,c, , ) were able to logically support that the salvaged blood was devoid of tumour cells and safe for transfusion.…”