Flow cytometric DNA ploidy in salivary gland tumours

Driemel, Oliver; Maier, H.; Kraft, K.; Haase, S.; Hemmer, Joerg

doi:10.3892/or.13.1.161

Cited by 8 publications

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“…The finding of 27% aneuploid cases in the current series actually calls attention to the problem of distinguishing diploid malignancies from benign salivary gland tumours, which typically are diploid as well 5,13,18 . While the importance of DNA ploidy for malignancy grading is evident, little is known about the contribution of the simultaneous DNA flow cytometric parameter, SPF.…”

Section: Discussionmentioning

confidence: 92%

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Flow cytometric S-phase fraction contributes to diagnosis of diploid malignant salivary gland tumours

Driemel

Kraft

Hemmer

2006

International Journal of Oral and Maxillofacial Surgery

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Section: Discussionmentioning

confidence: 92%

“…Most likely due to the low incidence of malignant salivary gland tumours, only a few attempts have been made to employ DNA ploidy analysis for diagnostic assessment. Recent reviews of published records emphasized 2 key findings 5,13 . First, benign salivary gland neoplasms are consistently DNA diploid.…”

mentioning

confidence: 98%

Flow cytometric S-phase fraction contributes to diagnosis of diploid malignant salivary gland tumours

Driemel

Kraft

Hemmer

2006

International Journal of Oral and Maxillofacial Surgery

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“…The DNA ploidy status has been previously investigated in salivary gland tumors and showed that only malignant tumors are aneuploid (6)(7)(8). However, the frequency of aneuploidy in this group of lesions is lower than in other solid tumors (9).…”

Section: Introductionmentioning

confidence: 97%

DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression

et al. 2017

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Chromosomal instability, leading to aneuploidy, is one of the hallmarks of human cancers. USP44 (ubiquitin specific peptidase 44) is an important molecule that plays a regulatory role in the mitotic checkpoint and USP44 loss causes chromosome missegregation, aneuploidy and tumorigenesis in vivo. In this study, it was investigated the immunoexpression of USP44 in 28 malignant salivary gland neoplasms and associated the results with DNA ploidy status assessed by image cytometry. USP44 protein was widely expressed in most of the tumor samples and no clear association could be established between its expression and DNA ploidy status or tumor size. On this basis, it may be concluded that the aneuploidy of the salivary gland cancers included in this study was not driven by loss of USP44 protein expression.

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“…Da Teilergebnisse dieser mit 279 Fällen umfangreichsten Studie bereits an anderer Stelle veröffentlicht wurden [9,10,23], soll hier ein kritischer Überblick über die klinische Bedeutung hoch-auflösender DNA-Durchflusszytophotometrie für die Dignitätsdiagnostik bei Tumoren der Speicheldrüsen im Vordergrund stehen. [24,25].…”

Section: Introductionunclassified

DNA-Ploidie und proliferative Aktivität bei Speicheldrüsentumoren

Driemel

Kraft

Hemmer

2007

Mund Kiefer GesichtsChir

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ZusammenfassungMithilfe hoch-auflösender DNA-Durchflusszytophotometrie wurden DNA-Ploidie und SPhasenfraktion (SPF) bei 279 Speicheldrüsentumoren bestimmt. Alle 229 benignen Neoplasien waren diploid; 12 von 50 malignen Tumoren wiesen Zellpopulationen mit aneuploidem DNA-Gehalt auf. Die SPF-Werte der diploiden Malignome waren signifikant höher als bei pleomorphen Adenomen, unterschieden sich jedoch nicht von denen der Zystadenolymphome (Warthin-Tumoren). Während Aneuploidie ein Malignitätsmerkmal darstellt, ist der SPF-Wert für die Dignitätsdiagnostik bei Speicheldrüsentumoren nur von eingeschränktem Nutzen.DNA ploidy and proliferative activity in salivary gland tumours Abstract DNA ploidy and S-Phase fraction (SPF) of 279 salivary gland tumours were analysed using high-resolution DNA flow cytometry. All 229 benign neoplasms were diploid while 12 of 50 malignant tumours showed cell populations with aneuploid DNA content. The SPF values of diploid malignancies were significantly higher if compared with pleomorphic adenomas but did not differ from that of the zystadenolymphoma (Warthin tumour) group. While aneuploidy represents a distinct indicator of malignancy SPF values are of minor relevance for dignity assessment in salivary gland tumours.(Vortrag gehalten bei der 36. Jahrestagung des Deutsch-Österreichisch-Schweizerischen Arbeitskreises für

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Flow cytometric DNA ploidy in salivary gland tumours

Cited by 8 publications

References 0 publications

Flow cytometric S-phase fraction contributes to diagnosis of diploid malignant salivary gland tumours

Flow cytometric S-phase fraction contributes to diagnosis of diploid malignant salivary gland tumours

DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression

DNA-Ploidie und proliferative Aktivität bei Speicheldrüsentumoren

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