Flourensia retinophylla: An outstanding plant from northern Mexico with antibacterial activity

Rodríguez, Diana Jasso de; Victorino-Jasso, M.C.; Rocha‐Guzmán, Nuria Elizabeth; Moreno‐Jiménez, Martha Rocío; Jiménez, Lourdes Díaz; Rodrı́guez-Garcı́a, R.; Quintanilla, José Ángel Villarreal; Peña-Ramos, Fidel Maximiano; Carrillo-Lomelí, D.A.; Genisheva, Zlatina; Flores-López, María L.

doi:10.1016/j.indcrop.2022.115120

Cited by 1 publication

(2 citation statements)

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“…The biological potential of this plant could be associated with the nature of the chemical compounds present in the plant. Previously, our work group demonstrated the presence of bioactive compounds such as flavonoids, phenolic acids, and terpenes in this extract [ 14 , 15 ], which have been shown to exhibit antimicrobial effects against S. aureus , such as apigenin (MIC: 31.25 µg/mL), quercetin (MIC: 300 µg/mL), ellagic acid (MIC: 128 µg/mL) and phytol (MIC: >1000 µg/mL) [ 21 , 22 , 23 , 24 ].…”

Section: Resultsmentioning

confidence: 99%

“…blake, a plant known as “yerba de mula”, is widely distributed in Coahuila, Mexico and it is used in traditional medicine against infections [ 14 ]. Recent research has provided information about different biological activities such as antimicrobial; however, its antimicrobial effect against S. aureus has not been reported and its antibiofilm effect has not been studied [ 14 , 15 , 16 ]. The biological potential of this plant is associated with the presence of bioactive compounds, especially phenolic compounds and terpenes [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Antimicrobial and Antibiofilm Potential of Flourensia retinophylla against Staphylococcus aureus

Beltrán-Martínez,

Tapia-Rodríguez,

Ayala-Zavala

et al. 2024

Plants

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Staphylococcus aureus is a Gram-positive bacteria with the greatest impact in the clinical area, due to the high rate of infections and deaths reaching every year. A previous scenario is associated with the bacteria’s ability to develop resistance against conventional antibiotic therapies as well as biofilm formation. The above situation exhibits the necessity to reach new effective strategies against this pathogen. Flourensia retinophylla is a medicinal plant commonly used for bacterial infections treatments and has demonstrated antimicrobial effect, although its effect against S. aureus and bacterial biofilms has not been investigated. The purpose of this work was to analyze the antimicrobial and antibiofilm potential of F. retinophylla against S. aureus. The antimicrobial effect was determined using an ethanolic extract of F. retinophylla. The surface charge of the bacterial membrane, the K+ leakage and the effect on motility were determined. The ability to prevent and remove bacterial biofilms was analyzed in terms of bacterial biomass, metabolic activity and viability. The results showed that F. retinophylla presents inhibitory (MIC: 250 µg/mL) and bactericidal (MBC: 500 µg/mL) activity against S. aureus. The MIC extract increased the bacterial surface charge by 1.4 times and the K+ concentration in the extracellular medium by 60%. The MIC extract inhibited the motility process by 100%, 61% and 40% after 24, 48 and 72 h, respectively. The MIC extract prevented the formation of biofilms by more than 80% in terms of biomass production and metabolic activity. An extract at 10 × MIC reduced the metabolic activity by 82% and the viability by ≈50% in preformed biofilms. The results suggest that F. retinophylla affects S. areus membrane and the process of biofilm formation and removal. This effect could set a precedent to use this plant as alternative for antimicrobial and disinfectant therapies to control infections caused by this pathogen. In addition, this shrub could be considered for carrying out a purification process in order to identify the compounds responsible for the antimicrobial and antibiofilm effect.

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