Floristic and Structural Composition of Wonderwoud Forest in the Wolkberg, North-Eastern Transvaal

Geldenhuys, C. J.; Pieterse, F. J.

doi:10.1080/00382167.1993.9629372

Cited by 5 publications

(3 citation statements)

References 2 publications

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“…Van Wyk and Prinsloo [48] evaluated both the seasonal and regional metabolite profiling of the stem bark using NMR. The clustering of the samples, Currently, the plant species is threatened and is found mostly in conserved areas, which include parks, forests, and botanical gardens in Southern Africa [18][19][20][21][22][23][24][25][26][27]. Although the plant species is still available in some parts of South Africa, it is highly threatened by bark stripping for medicinal purposes [28].…”

Section: Phytochemistrymentioning

confidence: 99%

A Systematic Review of Curtisia dentata Endemic to South Africa: Phytochemistry, Pharmacology, and Toxicology

Raletsena,

Pooe,

Mongalo

2023

Life

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The use of traditional medicine in treating a variety of both human and animal infections is ancient and still relevant. This is due to the resistance exhibited by most pathogenic microbial stains to currently-used antibiotics. The current work reports the phytochemistry, ethno-medicinal uses, toxicology, and most important pharmacological activities that validate the use of the plant species in African traditional medicine. Curtisia dendata is used in the treatment of many human and animal infections, including diarrhea, skin and related conditions, sexually transmitted infections, cancer, and a variety of ethno-veterinary infections. Pharmacologically, the plant species exhibited potent antimicrobial activity against a variety of pathogens. Further, both extracts and compounds isolated from the plant species exhibited potent antioxidant, anticancer, anti-parasitic, anti-inflammatory, and other important biological activities. Phytochemically, the plant species possess a variety of compounds, particularly triterpenes, that may well explain the various pharmacological activities of the plant species. The toxicological parameters, antimicrobial activities against microorganisms related to sexually transmitted infections, anti-diabetic effects, and inflammatory properties of the plant species are not well studied and still need to be explored. The biological activities observed validate the use of the plant species in African traditional medicine, particularly in the treatment of pulmonary infections associated with Mycobacterium species, and may well be due to the presence of triterpenes prevalent in the leaves.

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Section: Phytochemistrymentioning

confidence: 99%

A Systematic Review of Curtisia dentata Endemic to South Africa: Phytochemistry, Pharmacology, and Toxicology

Raletsena,

Pooe,

Mongalo

2023

Life

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“…It is a shrub or a medium-sized tree up to 15 m high occurring in Southern Asia, Republic of South Africa, Ethiopia, Zimbabwe, Kenya, and Tanzania. 9 − 11 The plant is locally known as “mkumbi” in Tanzania. There is no ethnomedical information reported for this plant species, apart from its use to relinquish evil spirits from children.…”

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confidence: 99%

“…Members of this genus are used in traditional medicine to treat malaria, diarrhea, and hemorrhoids, as well as microbial and helminthic ailments. , Many species from the genus Ochna are known to metabolize biflavanones, chalcones, and related compounds , which are reported to exhibit antimalarial and antibacterial activity and cytotoxicity against cancer cells. − In our endeavor to search for bioactive natural products from Tanzanian medicinal plants, we investigated extracts of O. holstii . It is a shrub or a medium-sized tree up to 15 m high occurring in Southern Asia, Republic of South Africa, Ethiopia, Zimbabwe, Kenya, and Tanzania. − The plant is locally known as “mkumbi” in Tanzania. There is no ethnomedical information reported for this plant species, apart from its use to relinquish evil spirits from children.…”

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confidence: 99%

Biflavanones, Chalconoids, and Flavonoid Analogues from the Stem Bark of Ochna holstii

et al. 2021

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Two new biflavanones ( 1 and 2 ), three new bichalconoids ( 3 – 5 ), and 11 known flavonoid analogues ( 6 – 16 ) were isolated from the stem bark extract (CH 3 OH–CH 2 Cl 2 , 7:3, v/v) of Ochna holstii . The structures of the isolated metabolites were elucidated by NMR spectroscopic and mass spectrometric analyses. The crude extract and the isolated metabolites were evaluated for antibacterial activity against Bacillus subtilis (Gram-positive) and Escherichia coli (Gram-negative) as well as for cytotoxicity against the MCF-7 human breast cancer cell line. The crude extract and holstiinone A ( 1 ) exhibited moderate antibacterial activity against B. subtilis with MIC values of 9.1 μg/mL and 14 μM, respectively. The crude extract and lophirone F ( 14 ) showed cytotoxicity against MCF-7 with EC 50 values of 11 μg/mL and 24 μM, respectively. The other isolated metabolites showed no significant antibacterial activities (MIC > 250 μM) and cytotoxicities (EC 50 ≥ 350 μM).

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Phylogenetic analysis of East and southern African Memecylon section Buxifolia (Melastomataceae): Insights on patterns and processes of diversification

Stone

Cassimjee

Mncwabe

2017

South African Journal of Botany

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Floristic and Structural Composition of Wonderwoud Forest in the Wolkberg, North-Eastern Transvaal

Cited by 5 publications

References 2 publications

A Systematic Review of Curtisia dentata Endemic to South Africa: Phytochemistry, Pharmacology, and Toxicology

A Systematic Review of Curtisia dentata Endemic to South Africa: Phytochemistry, Pharmacology, and Toxicology

Biflavanones, Chalconoids, and Flavonoid Analogues from the Stem Bark of Ochna holstii

Phylogenetic analysis of East and southern African Memecylon section Buxifolia (Melastomataceae): Insights on patterns and processes of diversification

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