Florid cutaneous papillomatosis with acanthosis nigricans in a patient with carcinomas of the lung and prostate

Weger, Wolfgang; Ginter‐Hanselmayer, Gabriele; Hammer, Heinz F.; Hödl, S

doi:10.1016/j.jaad.2006.02.002

Cited by 10 publications

(5 citation statements)

References 9 publications

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“…No epidermal inclusion bodies were observed and polymerase chain reaction analysis of human papilloma virus DNA in the mucosal region was negative. These findings were compatible with a diagnosis of AN [1, 13, 14, 15]. …”

Section: Case Reportsupporting

confidence: 78%

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A Case of Generalized Acanthosis Nigricans with Positive Lupus Erythematosus-Related Autoantibodies and Antimicrosomal Antibody: Autoimmune Acanthosis Nigricans

et al. 2012

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Acanthosis nigricans (AN) is a hyperpigmented keratotic skin lesion known to be associated with malignant disease and endocrinopathy. We report a very rare case of generalized AN with Sjögren’s syndrome- and systemic lupus erythematosus-like features but without type B insulin resistance. Neither internal malignancy nor other endocrinological disorders, including glucose intolerance, were detected during a 10-year clinical course with benign diffuse papillomatosis extending from the mucosa of the larynx to the esophagogastric junction. The case was complicated with chronic thyroiditis and interstitial pneumonia, which were not treated with any medication. AN skin lesions and mucosal papillomatosis regressed with oral cyclosporine A, accompanied by the lowering of autoantibody titers. This is the first report of generalized AN involving an area from the mucosa of the larynx to the esophagogastric junction accompanied by autoimmune manifestations which responded to systemic immunosuppressive therapy.

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Section: Case Reportsupporting

confidence: 78%

“…Malignancy-associated AN tends to be extensive and involves mucosal surfaces, mostly in elderly people. The majority of associated malignancies are intra-abdominal adenocarcinomas, most commonly gastric cancer [1, 13, 15]. In our case, the results of repeated examinations over a 10-year clinical course excluded malignancy-associated AN.…”

Section: Discussionmentioning

confidence: 68%

A Case of Generalized Acanthosis Nigricans with Positive Lupus Erythematosus-Related Autoantibodies and Antimicrosomal Antibody: Autoimmune Acanthosis Nigricans

et al. 2012

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“…ANM is mainly associated with intra-abdominal malignancies (70–90%), especially gastric adenocarcinoma [ 3 ]. An association with prostate cancer is uncommon; to our knowledge, only a few such cases have been reported [ 3 , 5 , 13 , 14 ]. Results of treatment aimed at relief of accompanying symptoms such as pruritus and pain in the oral cavity or anus, remain disappointing.…”

Section: Discussionmentioning

confidence: 99%

Malignant acanthosis nigricans associated with prostate cancer: a case report

et al. 2014

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BackgroundAcanthosis nigricans is characterized by hyperpigmentation and hyperkeratosis of the skin or mucous membranes. Its malignant form is associated with internal neoplasms, especially gastric adenocarcinoma (55–61%). Coexistence with prostate cancer is uncommon. In the paraneoplastic type of this dermatosis, the skin and mucous lesions are characteristically of more sudden onset and more severe than those in the benign form. The efficacy of various treatment strategies remains disappointing.Case presentationWe here report a case of 66-year-old Caucasian patient with metastatic prostate cancer and a mild form of acanthosis nigricans that preceded the diagnosis of malignancy and resolved with chemotherapy in parallel with the prostate cancer. The dermatosis recurred when the prostate cancer progressed.ConclusionConcurrent acanthosis nigricans and prostate cancer is rare, and few such cases have been reported. Anti-tumor therapy occasionally results in regression of this dermatosis. Underlying malignant disease should be suspected in individuals with elderly-onset of acanthosis nigricans.

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“…Pruritus is an important accompanying symptom that should not be overlooked since it may precede the skin lesions. 5 FCP is most commonly associated with gastric adenocarcinoma but is also described in the lung, breast, bladder, uterus, ovary, and prostate cancers. 4 To our knowledge, this is the first case described of an asymptomatic ovarian serous carcinoma presenting with both AN and FCP at the time of the diagnosis.…”

Section: E T T E R S T O T H E E D I T O R Florid Cutaneous Papilloma...mentioning

confidence: 99%

Florid cutaneous papillomatosis and acanthosis nigricans as cutaneous findings in a patient with ovarian carcinoma

Lee

Naldi

Pierobon

et al. 2023

J of Cosmetic Dermatology

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Florid cutaneous papillomatosis with acanthosis nigricans in a patient with carcinomas of the lung and prostate

Cited by 10 publications

References 9 publications

A Case of Generalized Acanthosis Nigricans with Positive Lupus Erythematosus-Related Autoantibodies and Antimicrosomal Antibody: Autoimmune Acanthosis Nigricans

A Case of Generalized Acanthosis Nigricans with Positive Lupus Erythematosus-Related Autoantibodies and Antimicrosomal Antibody: Autoimmune Acanthosis Nigricans

Malignant acanthosis nigricans associated with prostate cancer: a case report

Florid cutaneous papillomatosis and acanthosis nigricans as cutaneous findings in a patient with ovarian carcinoma

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