Florid Breast Fibroadenomas in Patients Taking Hormonal Oral Contraceptives

Ve, Goldenberg; Wiegenstein, Louise; Nk, Mottet

doi:10.1093/ajcp/49.1.52

Cited by 50 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Three fibroadenomas with florid epithelial proliferation of the type described by Goldenberg et al (1968) and by Brown (1970) as occurring in association with the use of oral contraceptives were found. Two of these lesions occurred in women who had never used oral contraceptives, while the third occurred in a woman who had used oral contraceptives for only one month almost two years before the presence of a lump in the breast was first discovered.…”

Section: Histopathology Of Excised Materialsmentioning

confidence: 84%

“…Fechner (1970aFechner ( , 1970bFechner ( , 1970c examined 54 fibroadenomas, 25 specimens of tissue classified as chronic cystic disease, and five breast cancers removed from women receiving oral contraceptives; he found no distinctive features which he could relate to use of the steroids. As mentioned above, however, Goldenberg et al (1968) and Brown (1970) reported on four patients and one patient respectively who were using oral contraceptives and who were treated for fibroadenomas showing a bizarre type of epithelial proliferation thought possibly to be related to the use of the preparations. Our experience has been in line with that of Fechner; we have found it impossible to distinguish lesions, benign or malignant, excised from the breasts of women using oral contraceptives from those excised from the breasts of women not doing so.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Oral Contraceptives and Breast Neoplasia: A Retrospective Study

Vessey¹,

Doll²,

Sutton³

1972

BMJ

116

View full text Add to dashboard Cite

Section: Histopathology Of Excised Materialsmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Oral Contraceptives and Breast Neoplasia: A Retrospective Study

Vessey¹,

Doll²,

Sutton³

1972

BMJ

116

View full text Add to dashboard Cite

“…3). The epithelial changes along with microcysts and intraluminar secretion observed in this case may be due to the intake of oral contraceptives, although those features are not specific [2,3]. One may speculate that the stromal component may have induced such changes as occur in some biphasic breast proliferations, such as in phyllodes tumors and complex fibroadenomas.…”

Section: Abstract Breast · Eosinophiliamentioning

confidence: 92%

Benign fibroepithelial breast lesion with inflammatory eosinophilic infiltration

Laforga

2002

Virchows Archiv

View full text Add to dashboard Cite

Keywords Breast · EosinophiliaSir, the presence of eosinophils encountered in female genital organs has been the subject of little attention. Their appearance in such tissues is considered to be an occasional accompaniment of a non-specific inflammation. In mammary tumors, eosinophilic inflammatory reaction has not been described as a peculiar feature. We describe a unique case of a fibroepithelial breast tumor with a striking eosinophilic infiltration in a 29-year-old female who had been taking oral contraceptives. A mammographic study showed a well-delimited nodule in her left breast. A fine-needle aspiration biopsy (FNAB) was performed, and a diagnosis of fibrocystic disease was rendered. The patient did not receive any intra-mammary injection of antibiotics or other medicaments during the FNAB. A chest X-ray was normal, as was her hematological profile. History of allergy and parasitic infestation was denied.Nine months later, the nodule was surgically removed. On gross examination, the nodule measured 1 cm in diameter and at cut surface exhibited a central solid tan-colored area with cystic spaces containing fluid at the periphery. Microscopically, the lesion showed biphasic architecture (Fig. 1). The stromal component was monomorphic and fibrous, with bland nuclear features and contained a polymorphous inflammatory cell infiltrate of lymphocytes, plasma cells, histiocytes and a striking number of eosinophils, particularly in the periphery of the cysts (Fig. 2). The epithelial component showed small cysts lined by hyperplastic epithelium and apocrine metaplasia. The epithelial cells showed increased proliferative activity with scattered typical mitoFig. 1 Low-power view showing a nodular appearance of the fibroepithelial lesion containing microcysts with micropapillary projections. Note the striking inflammatory stromal reaction rich in eosinophils. Hematoxylin and eosin ×100 Fig. 2 The epithelium component shows hyperplasia and intermixed eosinophils. The stroma shows a heavy inflammation. Hematoxylin and eosin ×200

show abstract

“…Instances of fibroadenomas in women using oral contraceptives have been reported (55,57,58). Instances of fibroadenomas in women using oral contraceptives have been reported (55,57,58).…”

Section: Effect Of Oral Contraceptivesmentioning

confidence: 99%

Oral Contraceptives: Relation to Mammary Cancer, Benign Breast Lesions, and Cervical Cancer

Va¹

1975

Annu. Rev. Pharmacol.

View full text Add to dashboard Cite

The results of experimental studies on the relationship of estrogens and oral contraceptives to mammary lesions demonstrate that the type of response obtained depends largely on the species and strain of animal that is employed. A variety of clinical studies has failed to demonstrate that estrogen can cause mammary cancer, this lack of effort correlates with the results obtained in various studies in animals. Similar relationships exist for oral contraceptives, and the clinical data show good agreement in demonstrating that the contraceptive steroids do not have a tumorigenic effect on the human mammary gland. Estrogen can increase the occurrence of cervical cancer in certain strains of mice, but apparently this effect is not observed in other species of animals, including man. The preponderance of data shows that oral contraceptives do not adversely affect the occurence of abnormal Papanicolaou smears, cervical dysplasia, cervical cancer in situ, or invasive cervical cancer.

show abstract

Florid Breast Fibroadenomas in Patients Taking Hormonal Oral Contraceptives

Cited by 50 publications

References 0 publications

Oral Contraceptives and Breast Neoplasia: A Retrospective Study

Oral Contraceptives and Breast Neoplasia: A Retrospective Study

Benign fibroepithelial breast lesion with inflammatory eosinophilic infiltration

Oral Contraceptives: Relation to Mammary Cancer, Benign Breast Lesions, and Cervical Cancer

Contact Info

Product

Resources

About