Florfenicol in Atlantic salmon, Salmo salar L.: field evaluation of efficacy against furunculosis in Norway

Abstract

The efficacy of florfenicol in the control of natural outbreaks of furunculosis in Atlantic siiltnon, SatiHO sutitr L. was cvalucitcd on five Norwegian farms duntig the sutnmcr of 1992. A total of 115 245 first-or second-generation fish received florfenicol with feed at a dose rate of lOmgkg"' body weight daily for 10 eonseeutivc days. Comparisons were made with similar pens offish medicated with the preferred treatment for eaeh location. In the 10 days following introduction of therapy, all treatments were associated with a rapid decline in mortality caused by infection with Aeromonas satmontcida. Florfenicol-medicated salmon had a lower specific mortality than those given oxolinic acid, flumequine or a trimethoprim and sulphadiazine eombination. No adverse reaetions to treatment with florfenieol were observed.

Pharmacokinetics and Bioequivalence of Florfenicol Oral Solution Formulations (Flonicol® and Veterin®10%) in Broiler Chickens

“…The efficacy of florfenicol has been demonstrated against many diseases of domestic animals [8][9][10][11][12][13][14]. However, to date, studies on the efficacy of florfenicol using pharmacokinetic/ pharmacodynamic (PK/ PD) approaches have not been carried out in poultry.…”

Bioavailability and pharmacokinetics of florfenicol in healthy sheep*

“…Florfenicol preparations in published study reports include injection, food premix, implant, etc. Its efficacy has been demonstrated against many infectious diseases of domestic animals (Nordmo et al. , 1994; Ueda & Suenaga, 1995; Booker et al.…”

The influence of in vitro and in vivo exposure to antibiotics on mitogen-induced proliferation of lymphoid cells in rainbow trout (Oncorhynchus mykiss)

“…Florfenicol is not licenced for use for fish in Finland but has proved to be an e$cient and promising drug in aquaculture. The recommended dose rate for this drug is 10 mg kg 1 fish per day for 10 days (Inglis & Richards, 1991;Nordmo et al, 1994).…”