Floral extract of Tecoma stans: A potent inhibitor of gentamicin-induced nephrotoxicity in vivo

Raju, S; Kavimani, S; rao, V Uma Maheshwara; Reddy, K Sreeramulu; Kumar, G V Narasimha

doi:10.1016/s1995-7645(11)60173-9

Cited by 27 publications

(17 citation statements)

References 23 publications

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“…Gentamicin is a well-known potent, broad spectrum aminoglycoside antibiotic with a low cost and high effectiveness when used against Gram-negative infections (Banday et al, 2008;Salem et al, 2010). However, gentamicin use has been restricted and gentamicin is used carefully owing to its effect of causing nephrotoxicity and hepatotoxicity (Stojiljkovic and Stoiljkovic, 2006;Raju et al, 2011;Nayma et al, 2012;Masakazu et al, 2014). The present study has shown the effects of HPE and how it develops gentamicin-induced nephrotoxicity in rats.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence has indicated that the renal toxicity of gentamicin is due to its selective accumulation in the renal proximal convoluted tubules and its long-term stay, which subsequently leads to the loss of brush border integrity, severe degeneration (vacuolar or hydrophic degeneration) and necrosis in epithelial cells of the proximal tubules, and mononuclear cells have infiltrated in intertubular areas (Raju et al, 2011;Liu et al, 2016;Veljković et al, 2016). In this study, gentamicin-administered group (Group IV) showed congestion and dilatation in the renal blood vessels and severe degeneration (vacuolar or hydrophic degeneration) and necrosis in epithelial cells of the proximal tubules.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Helichrysum plicatum DC. subsp. plicatum ethanol extract on gentamicin-induced nephrotoxicity in rats

Yıldırım

Kordalı

Kapakin

et al. 2017

J. Zhejiang Univ. Sci. B

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The aim of this study was to evaluate the possible therapeutic or protective effects of Helichrysum plicatum DC. subsp. plicatum ethanol extract (HPE) against gentamicin-induced nephrotoxicity. Thirty-six Sprague Dawley male rats weighing between 200 and 250 g were used as live material. They were formed into six groups containing 6 rats each and were allowed to adapt to laboratory conditions for 7 d. Group I: control, 5% DMSO intraperitoneal (i.p.); Group II: HPE 100 mg/(kg·d) i.p.; Group III: HPE 200 mg/(kg·d) i.p.; Group IV: gentamicin as 80 mg/(kg·d) i.p.; Group V: gentamicin as 80 mg/(kg·d) i.p.+HPE 100 mg/(kg·d) i.p.; and Group VI: gentamicin as 80 mg/(kg·d) i.p.+HPE 200 mg/(kg·d) i.p. for 8 d. Following treatment, serum, liver, and kidney tissues were used to assess blood urea nitrogen (BUN), creatinine, enzymatic and non-enzymatic antioxidants, and lipid peroxidation. Gentamicin significantly increased serum BUN, creatinin, and liver and kidney levels of malondialdehyde (MDA). It also decreased the activity of catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD). Treatment with the HPE 100 mg/kg reversed gentamicin-induced alterations as evidenced by decreased serum BUN and creatinin, liver and kidney oxidant marker, and tubular necrosis as well as by an increase in antioxidant enzymes. It was found that HPE 200 mg/kg significantly increased liver and kidney tissue MDA levels in nephrotoxicity in rats. As a result, these findings support the proposition that HPE in 100 mg/kg dose demonstrates in the kidney and liver as free radicals and scavenger to prevent the toxic effects of gentamicin in both the biochemical and histopathology parameters.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Helichrysum plicatum DC. subsp. plicatum ethanol extract on gentamicin-induced nephrotoxicity in rats

Yıldırım

Kordalı

Kapakin

et al. 2017

J. Zhejiang Univ. Sci. B

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“…Animals were weighed once a week and drug dosage was adjusted based on body weight changes. In each group, one third of the rats were sacrificed via exsanguination following anesthesia with chloral hydrate (350 mg/kg) after 20 days of administration (n=10), one third after 40 days of administration (n=10) and one third after 20 days of convalescence (n=10) ( 25 ).…”

Section: Methodsmentioning

confidence: 99%

Oral colon-specific drug delivery system reduces the nephrotoxicity of rhubarb anthraquinones when they produce purgative efficacy

Liu¹,

Wei²,

Chang³

et al. 2017

Experimental and Therapeutic Medicine

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Rhubarb is commonly used to treat constipation in China and anthraquinones (AQs) are the active components present in rhubarb. However, an increasing number of studies have reported that AQs induce nephrotoxicity. In the present study, rhubarb total free anthraquinones (RTFA) oral colon-specific drug delivery granules (RTFA-OCDD-GN) were prepared to determine whether RTFA-OCDD-GN could reduce the nephrotoxicity that occurs when AQs produce purgative efficacy. RTFA-OCDD-GN were prepared using pH-enzyme double-layer coating technology and the cumulative release rate of RTFA in RTFA-OCDD-GN was assessed. The first black stool time, the number and state of feces over 8 h were observed to measure the purgative efficacy. In the nephrotoxicity test, biochemical and histopathological examinations were performed following 20 and 40 days administration, and 20 days convalescence. The cumulative release rate of RTFA in RTFA-OCDD-GN was >80% in simulated colonic fluid. RTFA-OCDD-GN produced considerable purgative efficacy compared with rhubarb medical material samples (RMMS). Following 40 days RMMS administration, blood urea nitrogen, creatinine and urine β2-microglobulin levels in the high-dosage group were significantly increased compared with the control and RTFA-OCDD-GN groups (P<0.05). All specimens from the high-dosage RMMS group exhibited swelling/degeneration of renal proximal convoluted tubule epithelial cells. No difference in pathological conditions and biochemical indicators was detected between the RTFA-OCDD-GN groups and the control group. The nephrotoxicity of AQs was significantly reduced following RTFA-OCDD-GN administration, which produced considerable purgative efficacy compared with RMMS.

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“…Evaluation of nephroprotective activity [7,8] Rats were randomly assigned into 4 groups of each 6 animals each. Group-I was kept as normal control receiving saline (0.5 mL, i.p.)…”

Section: Experimental Animals and Proceduresmentioning

confidence: 99%

Protective effect of Cissampelos pareira linn. Extract on gentamicin-induced nephrotoxicity and oxidative damage in rats

Reddy¹,

Kumar²,

Swamy³

et al. 2014

Phcog J.

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Objective: To evaluate the potential nephroprotective and antioxidant activity of hydroalcoholic Cissampelos pareira (C. pareira) whole plant extract using gentamicin-induced rats. Methods: For studying acute toxicity study, single oral dose of 2g/kg hydroalcoholic extract of C. pareira was evaluated in rats by oral gavage. The nephroprotective activity was evaluated using gentamicin-induced model in rats. In-vitro antioxidant activity was evaluated by using DPPH assay and reducing power assay. In-vivo antioxidant activity was evaluated by using glutathione and lipid peroxidation estimations in gentamicin-induced rats. Hydroalcoholic C. pareira whole plant extract was given at a dose of 200 and 400 mg/kg p.o. Results: For acute toxicity testing rats administered with the extract at a dose 2 g/ kg. the result showed no toxicity. Hydroalcoholic C. Pareira whole plant extract (200 and 400 mg/kg p.o) significantly decrease the elevated urinary glucose levels in the urine, decrease the elevated urea and creatinine levels in blood and increase the urinary creatinine levels in gentamicin-induced nephrotoxic rats. The extract had shown significant dose dependent increase in the DPPH and reducing power activity. There were a dose dependent decreasing and increasing of lipid peroxidation, glutathione levels in hydoalcoholic extract treated groups respectively. Conclusion: This study exhibits that hydroalcoholic C. pareira whole plant extract poses nephroprotective activity which may be due to its antioxidant activity.

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Floral extract of Tecoma stans: A potent inhibitor of gentamicin-induced nephrotoxicity in vivo

Abstract: The present study indicates a very important role of reactive oxygen species (ROS) and the relation to renal dysfunction and point to the therapeutic potential of Tecoma stans in gentamicin induced nephrotoxicity.

Cited by 27 publications

References 23 publications

Effect of Helichrysum plicatum DC. subsp. plicatum ethanol extract on gentamicin-induced nephrotoxicity in rats

Effect of Helichrysum plicatum DC. subsp. plicatum ethanol extract on gentamicin-induced nephrotoxicity in rats

Oral colon-specific drug delivery system reduces the nephrotoxicity of rhubarb anthraquinones when they produce purgative efficacy

Protective effect of Cissampelos pareira linn. Extract on gentamicin-induced nephrotoxicity and oxidative damage in rats

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