Floods in Cuyama Valley, California, February 1998

Bowers, J.C.; Houston, Ernest R.

doi:10.3133/fs16200

Cited by 5 publications

(2 citation statements)

References 1 publication

(1 reference statement)

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“…A second type of post‐flood investigations is conducted more systematically by technical services like the US Geological Survey (Bowers, 2001; Juracek et al , 2001; Carter et al , 2002; Winston and Criss, 2002), the Istituto di Ricerca per la Protezione Idrogeologica in Italy for instance or by research institutions (Hemain and Dourlens, 1989; Gilard and Mesnil, 1995). The aim is then to document the extreme events.…”

Section: Introductionmentioning

confidence: 99%

Post‐flood field investigations in upland catchments after major flash floods: proposal of a methodology and illustrations

Gaumé¹,

Borga²

2008

J Flood Risk Management

179

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Post‐event survey and investigation is one way to gain experience on natural hazards. The importance of the systematisation and standardisation of such investigations and re‐analysis is progressively recognised in all the geophysical sciences as shown by the growing number of scientific papers and programs on the subject. But how to proceed in the case of a flash floods, what type of data should be collected for what type of analyses and to explore which particular issues? To give a first answer to these questions, a methodology for post‐flash flood field investigations has been developed under the EC FLOODsite project and tested under the EC HYDRATE project. This paper presents shortly the principles of this methodology and illustrates its application for the study of two major flash floods that occurred in November 1999 and September 2002 in the South of France.

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Section: Introductionmentioning

confidence: 99%

Post‐flood field investigations in upland catchments after major flash floods: proposal of a methodology and illustrations

Gaumé¹,

Borga²

2008

J Flood Risk Management

179

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“…injections, steady-state was assumed 44 weeks after the loading dose, in accordance with previous studies. 20,21 Observations below the LLOQ were handled by setting the values at LLOQ/2. 22 Base and covariate models A stepwise procedure was used to identify the best model for cabotegravir concentrations after oral and i.m.…”

Section: Population Pharmacokinetic Analysismentioning

confidence: 99%

Population Pharmacokinetics of Cabotegravir Following Oral Administration and Long‐Acting Intramuscular Injection in Real‐World People with HIV

Thoueille,

Saldanha,

Schaller

et al. 2024

Clin Pharma and Therapeutics

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Long‐acting cabotegravir has been studied mainly in the stringent framework of clinical trials, which does not necessarily reflect the situation of people with HIV (PWH) in routine clinical settings. The present population pharmacokinetic analysis aims to build real‐world reference percentile curves of cabotegravir concentrations, accounting for patient‐related factors that may affect cabotegravir exposure. The second objective is to simulate whether dosing interval adjustments of cabotegravir could be considered in specific subpopulations. Overall, 238 PWH contributed to 1,038 cabotegravir levels (186 during the initial oral administration phase and 852 after intramuscular injection). Cabotegravir pharmacokinetics was best described using a one‐compartment model with distinct first order‐absorption for oral and intramuscular administrations, and identical volume and clearance. Our model showed almost 40% faster absorption and 30% higher clearance than previously reported, resulting in a time to steady‐state of 8 months and an elimination half‐life of 4.6 weeks for long‐acting cabotegravir. Sex and body mass index significantly influenced absorption, and bodyweight affected clearance. Model‐based simulations showed that cabotegravir trough concentrations in females were 25% lower 4 weeks after the intramuscular loading dose, but 42% higher during the late maintenance phase. Finally, simulations indicated that in females, despite significantly higher cabotegravir concentrations, longer intervals between injections may not consistently ensure levels above the 4‐fold protein‐adjusted 90% inhibitory target concentration.

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Dating alluvial deposits with optically stimulated luminescence, AMS 14C and cosmogenic techniques, western Transverse Ranges, California, USA

DeLong

Arnold

2007

Quaternary Geochronology

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Floods in Cuyama Valley, California, February 1998

Cited by 5 publications

References 1 publication

Post‐flood field investigations in upland catchments after major flash floods: proposal of a methodology and illustrations

Post‐flood field investigations in upland catchments after major flash floods: proposal of a methodology and illustrations

Population Pharmacokinetics of Cabotegravir Following Oral Administration and Long‐Acting Intramuscular Injection in Real‐World People with HIV

Dating alluvial deposits with optically stimulated luminescence, AMS 14C and cosmogenic techniques, western Transverse Ranges, California, USA

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