Abstract. We associate, to a Lagrangian submanifold L of a symplectic manifold, a new homology, called the cluster homology of L, which is invariant up to ambient symplectic diffeomorphisms. We discuss various applications concerning analytical, topological, and dynamical properties of Lagrangian submanifolds. We also deduce a new universal Floer homology, defined without obstruction, for pairs of Lagrangian submanifolds.