Floating solid cellulose nanofibre nanofoams for sustained release of the poorly soluble model drug furosemide

Svagan, Anna J.; Müllertz, Anette; Löbmann, Korbinian

doi:10.1111/jphp.12793

Cited by 20 publications

(24 citation statements)

References 34 publications

(88 reference statements)

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“…Advances in nanocellulose science have generated interest in using this material for drug delivery applications [33,34,35,36]. Indomethacin was loaded into a nanofibrillated cellulose (NFC) carrier to produce hierarchically structured hybrid structures [37].…”

Section: Introductionmentioning

confidence: 99%

Amorphisation of Free Acid Ibuprofen and Other Profens in Mixtures with Nanocellulose: Dry Powder Formulation Strategy for Enhanced Solubility

et al. 2019

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The formulation of arylpropionic acid derivatives (profens), which are poorly soluble Biopharmaceutical Classification System (BCS) Type II drugs, has a strong impact on their therapeutic action. This article shows that heat-treated powder mixtures of free acid profens with high surface area Cladophora cellulose induces drug amorphization and results in enhanced solubility and bioavailability. Similar mixtures produced using conventional low surface area cellulose, i.e., microcrystalline cellulose, does not produce the same effect. The concept is thoroughly described and links the solid-state characterization data, such as differential scanning calorimetry, X-ray powder diffraction, and Fourier-transform infra-red spectroscopy, with in vitro dissolution in biorelevant media and in vivo pharmacokinetic analysis in rats. The concept is demonstrated for several substances from the profens group, including ibuprofen (main model drug), ketoprofen, flurbiprofen, and naproxen. The presented approach opens new ways to produce solid dosage forms of profen drugs in their free acidic form as alternatives to existing analogues, e.g., drug-salt conjugates or soft gel liquid capsules.

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Section: Introductionmentioning

confidence: 99%

Amorphisation of Free Acid Ibuprofen and Other Profens in Mixtures with Nanocellulose: Dry Powder Formulation Strategy for Enhanced Solubility

et al. 2019

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“…In other words, a the drug release from fast to prolonged can be achieved from formulation based on CNF by changing the structure (film or foam) and the solid state form of the material and drug, respectively. [6][7][8] Solid foams could potentially be used as gastroretentive drug delivery systems, due to positive buoyancy. The prolonged release is a direct consequence of the cellular structure of the foams; the presence of stable and impermeable air-filled cavities in the foams create a highly tortuous diffusion path through the foam structure for the drug.…”

Section: Introductionmentioning

confidence: 99%

Toward Improved Understanding of the Interactions between Poorly Soluble Drugs and Cellulose Nanofibers

et al. 2018

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Cellulose nanofibers (CNFs) have interesting physicochemical and colloidal properties that have been recently exploited in novel drug-delivery systems for tailored release of poorly soluble drugs. The morphology and release kinetics of such drug-delivery systems heavily relied on the drug-CNF interactions; however, in-depth understanding of the interactions was lacking. Herein, the interactions between a poorly soluble model drug molecule, furosemide, and cationic cellulose nanofibers with two different degrees of substitution are studied by sorption experiments, Fourier transform infrared spectroscopy, and molecular dynamics (MD) simulation. Both MD simulations and experimental results confirmed the spontaneous sorption of drug onto CNF. Simulations further showed that adsorption occurred by the flat aryl ring of furosemide. The spontaneous sorption was commensurate with large entropy gains as a result of release of surface-bound water. Association between furosemide molecules furthermore enabled surface precipitation as indicated by both simulations and experiments. Finally, sorption was also found not to be driven by charge neutralization, between positive CNF surface charges and the furosemide negative charge, so that surface area is the single most important parameter determining the amount of sorbed drug. An optimized CNF-furosemide drug-delivery vehicle thus needs to have a maximized specific surface area irrespective of the surface charge with which it is achieved. The findings also provide important insights into the design principles of CNF-based filters suitable for removal of poorly soluble drugs from wastewater.

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“…To achieve the wet-stable foam, we used cellulose nanofibers in combination with a nontoxic surfactant (LA). 24 The g-C 3 N 4 nanosheets themselves have also been proposed to possess amphiphilic properties, 37 but this was not exploited in the present study. A schematic illustration of the different processing steps is found in Figure 2 a–c.…”

Section: Results and Discussionmentioning

confidence: 93%

“…The role of the surfactants is to change the surface energy of the CNFs, in order to facilitate their accumulation at the air bubble–water interface. 24 To realize this, it is important to use the precise amount of surfactant. 21 In Figure 2 d–f, representative images of the final dry foams and a close-up of the foam structure, both with and without g-C 3 N 4 , are shown.…”

Section: Results and Discussionmentioning

confidence: 99%

Floating Photocatalysts for Effluent Refinement Based on Stable Pickering Cellulose Foams and Graphitic Carbon Nitride (g-C₃N₄)

et al. 2020

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The transfer of heterogeneous photocatalysis applications from the laboratory to real-life aqueous systems is challenging due to the higher density of photocatalysts compared to water, light attenuation effects in water, complicated recovery protocols, and metal pollution from metal-based photocatalysts. In this work, we overcome these obstacles by developing a buoyant Pickering photocatalyst carrier based on green cellulose nanofibers (CNFs) derived from wood. The air bubbles in the carrier were stable because the particle surfactants provided thermodynamic stability and the derived photocatalytic foams floated on water throughout the test period (4 weeks). A metal-free semiconductor photocatalyst, g-C 3 N 4 , was facilely embedded inside the foam by mixing the photocatalyst with the air-bubble suspension followed by casting and drying to produce solid foams. When tested under mild irradiation conditions (visible light, low energy LEDs) and no agitation, almost three times more dye was removed after 6 h for the floating g-C 3 N 4 –CNF nanocomposite foam, compared to the pure g-C 3 N 4 powder residing on the bottom of a ca. 2 cm-high water pillar. The buoyancy and physicochemical properties of the carrier material were imperative to render escalated oxygenation, high photon utilization, and faster dye degradation. The reported assembly protocol is facile, general, and provides a new strategy for assembling green floating foams that can potentially carry a number of different photocatalysts.

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Floating solid cellulose nanofibre nanofoams for sustained release of the poorly soluble model drug furosemide

Abstract: Furosemide-loaded CNF-based foams with sustained release and buoyancy have been successfully prepared in a simple casting and drying procedure.

Cited by 20 publications

References 34 publications

Amorphisation of Free Acid Ibuprofen and Other Profens in Mixtures with Nanocellulose: Dry Powder Formulation Strategy for Enhanced Solubility

Amorphisation of Free Acid Ibuprofen and Other Profens in Mixtures with Nanocellulose: Dry Powder Formulation Strategy for Enhanced Solubility

Toward Improved Understanding of the Interactions between Poorly Soluble Drugs and Cellulose Nanofibers

Floating Photocatalysts for Effluent Refinement Based on Stable Pickering Cellulose Foams and Graphitic Carbon Nitride (g-C₃N₄)

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Floating solid cellulose nanofibre nanofoams for sustained release of the poorly soluble model drug furosemide

Abstract: Furosemide-loaded CNF-based foams with sustained release and buoyancy have been successfully prepared in a simple casting and drying procedure.

Cited by 20 publications

References 34 publications

Amorphisation of Free Acid Ibuprofen and Other Profens in Mixtures with Nanocellulose: Dry Powder Formulation Strategy for Enhanced Solubility

Amorphisation of Free Acid Ibuprofen and Other Profens in Mixtures with Nanocellulose: Dry Powder Formulation Strategy for Enhanced Solubility

Toward Improved Understanding of the Interactions between Poorly Soluble Drugs and Cellulose Nanofibers

Floating Photocatalysts for Effluent Refinement Based on Stable Pickering Cellulose Foams and Graphitic Carbon Nitride (g-C3N4)

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Product

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Floating Photocatalysts for Effluent Refinement Based on Stable Pickering Cellulose Foams and Graphitic Carbon Nitride (g-C₃N₄)