Floating Oral In-Situ Gel: A Review

Abstract

The drugs having a narrow absorption window in the gastrointestinal tract (GIT) when administered by oral route are often limited by poor bioavailability due to incomplete drug release and short residence time at the site of absorption. Novel drug delivery systems in the form of gastroretentive systems such as floating systems, mucoadhesive, high-density, expandable have been developed as they provide controlled delivery of drugs with prolonged gastric residence time. Liquid orals are more prone to low bioavailability because they are eliminated quickly from the stomach since they are subjected to faster transit from the stomach/ duodenum. The problems of immediate release and short gastrointestinal residence of liquids are eliminated by formulating as oral in situ gels as they provide the best means to overcome these problems The in situ gel dosage form is a liquid before administration and after it comes in contact with gastric contents due to one or more mechanisms gets converted to gel which floats on gastric contents. This achieves increased residence as well as sustained release. This approach is useful for systemic as well as local effect of drugs administered. This review gives a brief idea about floating oral in-situ gel formation and research done by various scientists on a number of drugs and polymers.
 Keywords: Floating drug delivery, gastric retention time, In-situ gel.

Design and development of gastro-retentive gel forming system comprising curcumin loaded Nanostructured lipid carrier for stomach specific delivery

“…In that, in situ gelling systems is a recent development and are versatile across administration routes. Offering advantages such as reduced dosing frequency, good patient compliance, improved bioavailability, cost effective and simple manufacturing process [4].…”

“…No toxicity was observed with a daily dose of 8 grams of curcumin for three months [3].Researchers performed the investigation on curcumin, and found that curcumin can reduce gastric ulcers by safeguarding the stomach mucus lining and inhibits the growth of ulcer causing organisms. 80 % of gastric ulcer is attributed to antiinflammatory drugs, 10 % of gastric ulcer by food culture and the other 10% by microorganisms [4].…”

Design and Evaluation of Gastro-Retentive Floating Tablets of Ibandronic acid

“…It is typically formulated as its sodium salt Ibandronate sodium. [5][6][7][8][9][10][11][12][13] Ibandronic acid', which suppresses the activity of osteoclasts and makes the bone stronger. Ibandronic acid may reverse bone loss by increasing bone mass and stopping more bone loss.…”

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“…The in-situ gel-forming drug delivery may be a variety of mucoadhesive drug delivery systems. These gels are liquescent at temperature but submit to gelation in swap body luids in pH [1]. May have a safety feature worldly belongings of room temperature dependant plus cation elicited gelation.…”