Floating Drug Delivery an Emerging Technology with Promising Market value

Devendiran, B; Mothilal, M; Damodharan, N

doi:10.5958/0974-360x.2020.00533.8

Cited by 4 publications

(2 citation statements)

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“…These systems employ various approaches like buoyancy, bio-adhesion, swelling, or geometrical factors to prolong the gastric residence time. 23 Both effervescent and non-effervescent systems aim to enhance the gastro-retentive properties of the dosage form and overcome the limitations of conventional oral drug delivery systems. 24 By prolonging the gastric residence time, these systems improve drug absorption, increase bioavailability, and optimize therapeutic outcomes.…”

Section: Effervescent Systemsmentioning

confidence: 99%

Gastro Retentive Drug Delivery System: Latest Approach towards Novel Drug Delivery

Prasad,

Parashar,

Khaudiyal

et al. 2023

IJPQA

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Various efforts have been undertaken to enhance the bioavailability and clinical performance of oral drug formulations. In pursuit of improving the therapeutic effectiveness of medications that are susceptible to degradation in alkaline pH environments, possess a limited window for absorption within the stomach, and readily dissolve under acidic conditions, a diverse range of gastro-retentive drug delivery systems (GRDDS) have been innovatively designed and developed. As a result, the stomach’s physiological state and the various factors that influence GRDDS will be discussed. As a rule, this survey will enlighten and coordinate enumerating scientists in arranging, plan, and planning the GRDDS.

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Section: Effervescent Systemsmentioning

confidence: 99%

Gastro Retentive Drug Delivery System: Latest Approach towards Novel Drug Delivery

Prasad,

Parashar,

Khaudiyal

et al. 2023

IJPQA

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“…The aforementioned tablets may be single-layered or bi-layered; in this latter case, the gas-generating agents are in one layer and the drug is added in the sustained-release portion layer [ 1 ]. Moreover, they are made of either natural polymers (Xanthan gum, Gellan gum chitosan, Guar gum, sodium alginate) or synthetic polymers (Eudragit, Ethylcellulose, hydroxypropyl cellulose) [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Controlled-Release Floating Bilayer Tablets of Esomeprazole and Clarithromycin

et al. 2022

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Controlled-release effervescent floating bilayer tablets reduce dosage frequency and improve patient compliance with enhanced therapeutic outcomes. Generally, two different tablets of clarithromycin and esomeprazole, respectively, are given for the treatment of Helicobacter pylori infection and it might be worth incorporating both in a single tablet. In the current study, controlled-release floating bilayer tablets of clarithromycin and esomeprazole (F1–F4) were developed with different rates of polymeric materials by a direct compression method. During the formulation, Fourier-transform infrared spectroscopy (FTIR) analysis was performed for possible interactions between drugs and excipients. No interactions between drugs and excipients were noted. Moreover, the bilayer tablets’ thickness, diameter, friability, hardness, weight variation, dissolution, and percent purity were found within the acceptable limits. The floating lag time and total floating time of all formulations were found to be < 25 s and 24 h, respectively. The release of both the clarithromycin and esomeprazole started at the same time from the controlled-release floating bilayer tablets by anomalous non-Fickian diffusion, and the polymeric materials extended the drug release rate up to 24 h. In the case of F1, the results approached ideal zero-order kinetics. The dissolution profiles of the tested and reference tablet formulations were compared, but no significant differences were observed. It can be concluded that such controlled-release effervescent floating bilayer tablets can be efficiently used in clinical practice to reduce dosage frequency and increase patient compliance with continuous drug release for 24 h, which ultimately might enhance therapeutic efficacy.

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Effervescent floating matrix tablets of a novel anti-cancer drug neratinib for breast cancer treatment

Rahamathulla

Alshahrani

Saqr

et al. 2021

Journal of Drug Delivery Science and Technology

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Floating Drug Delivery an Emerging Technology with Promising Market value

Cited by 4 publications

References 0 publications

Gastro Retentive Drug Delivery System: Latest Approach towards Novel Drug Delivery

Gastro Retentive Drug Delivery System: Latest Approach towards Novel Drug Delivery

Preparation and Characterization of Controlled-Release Floating Bilayer Tablets of Esomeprazole and Clarithromycin

Effervescent floating matrix tablets of a novel anti-cancer drug neratinib for breast cancer treatment

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