FLIP-2 Study

J, Figueras Aloy; Carbonell‐Estrany, Xavier; Quero-Jiménez, J.; Fernández-Colomer, Belén; Guzmán-Cabañas, J.; Echaniz-Urcelay, I.; Doménech-Martínez, E.

doi:10.1097/inf.0b013e3181710990

Cited by 110 publications

(68 citation statements)

References 20 publications

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“…A cohort study of 202 preterm children of 32 to 35 weeks GA who were hospitalized for RSV infection observed no deaths [47]. In another study of 1,583 preterm children ?32 weeks GA admitted with RSV infection, one death was observed [48].…”

Section: Resultsmentioning

confidence: 99%

“…Findings in this review varied between rates of 37.0 and 142.8 per 1,000 among preterm children ?32 weeks GA [20],[47],[52],[96]; 57.2 and 138.0 per 1,000 in preterm children 29-32 weeks GA [48],[96]; 23.5 and 29.5 per 1,000 in term children [96],[54]; and 1.8 per 1,000 in 1-4 year-olds [54]. In children ?2 years of age with congenital heart disease, admission rates ranged between 38 and 80 per 1,000 [23],[55].…”

Section: Resultsmentioning

confidence: 99%

“…A 2008 study reported that co-infection with two or more viruses increased the risk of admission up to 67.2% in children with pneumonia vs. 46.1% in the absence of co-infection [25]. Additional factors likely to increase the risk of admission three- and four-fold include: prematurity, low birth weight, immunosuppression, BPD, neurological issues, being ?10 weeks at the start of RSV season, breastfeeding under 2 months, school-age siblings, going to daycare, living with at least 4 adults, exposure to environmental pollution or tobacco smoke, maternal tobacco use during pregnancy, and family history of asthma [20],[21],[41],[47],[97]-[99]. Risk increases substantially in the presence of two or more of these factors [47].…”

Section: Resultsmentioning

confidence: 99%

“…Additional factors likely to increase the risk of admission three- and four-fold include: prematurity, low birth weight, immunosuppression, BPD, neurological issues, being ?10 weeks at the start of RSV season, breastfeeding under 2 months, school-age siblings, going to daycare, living with at least 4 adults, exposure to environmental pollution or tobacco smoke, maternal tobacco use during pregnancy, and family history of asthma [20],[21],[41],[47],[97]-[99]. Risk increases substantially in the presence of two or more of these factors [47]. Lower admission rates have been reported in the general population (children and adults) (0.553 per 1,000; 95% CI: 0.44-1.06) [54], although rates vary considerably based on comorbidity.…”

Section: Resultsmentioning

confidence: 99%

“…Findings in the studies reviewed ranged from 1.2 to 15 inpatient days [20]-[22],[24],[26],[29],[31],[32],[41],[47],[49],[56],[100],[101]. In children 32-35 weeks GA, the median duration was 7 days (interquartile range?=?4-10 days) [47]. In children 29-33 weeks GA the average number of days at the hospital was 7.4 ± 4.9 days and, in those 33-36 weeks GA, the average is 7.9 ± 6.0 days [100].…”

Section: Resultsmentioning

confidence: 99%

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Social, economic, and health impact of the respiratory syncytial virus: a systematic search

et al. 2014

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BackgroundBronchiolitis caused by the respiratory syncytial virus (RSV) and its related complications are common in infants born prematurely, with severe congenital heart disease, or bronchopulmonary dysplasia, as well as in immunosuppressed infants. There is a rich literature on the different aspects of RSV infection with a focus, for the most part, on specific risk populations. However, there is a need for a systematic global analysis of the impact of RSV infection in terms of use of resources and health impact on both children and adults. With this aim, we performed a systematic search of scientific evidence on the social, economic, and health impact of RSV infection.MethodsA systematic search of the following databases was performed: MEDLINE, EMBASE, Spanish Medical Index, MEDES-MEDicina in Spanish, Cochrane Plus Library, and Google without time limits. We selected 421 abstracts based on the 6,598 articles identified. From these abstracts, 4 RSV experts selected the most relevant articles. They selected 65 articles. After reading the full articles, 23 of their references were also selected. Finally, one more article found through a literature information alert system was included.ResultsThe information collected was summarized and organized into the following topics: 1. Impact on health (infections and respiratory complications, mid- to long-term lung function decline, recurrent wheezing, asthma, other complications such as otitis and rhino-conjunctivitis, and mortality; 2. Impact on resources (visits to primary care and specialists offices, emergency room visits, hospital admissions, ICU admissions, diagnostic tests, and treatments); 3. Impact on costs (direct and indirect costs); 4. Impact on quality of life; and 5. Strategies to reduce the impact (interventions on social and hygienic factors and prophylactic treatments).ConclusionsWe concluded that 1. The health impact of RSV infection is relevant and goes beyond the acute episode phase; 2. The health impact of RSV infection on children is much better documented than the impact on adults; 3. Further research is needed on mid- and long-term impact of RSV infection on the adult population, especially those at high-risk; 4. There is a need for interventions aimed at reducing the impact of RSV infection by targeting health education, information, and prophylaxis in high-risk populations.Electronic supplementary materialThe online version of this article (doi:10.1186/s12879-014-0544-x) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Social, economic, and health impact of the respiratory syncytial virus: a systematic search

et al. 2014

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Appropriateness of Age Thresholds for Respiratory Syncytial Virus Immunoprophylaxis in Moderate-Preterm Infants

et al. 2013

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IMPORTANCE Recommendations concerning the appropriate age threshold for respiratory syncytial virus (RSV) prophylaxis in moderate-preterm infants are highly debated. OBJECTIVE To determine the age at which moderate-preterm infants' risk of RSV hospitalization has decreased to the risk observed in low-risk term infants. DESIGN, SETTING, AND PARTICIPANTS Retrospective cohort study of Florida and Texas Medicaid fee-for-service billing records matched to birth certificates from Medicaid beneficiaries aged 0 to 12 months with a sibling younger than 5 years and without other indications for RSV prophylaxis between January 1, 1999, and December 31, 2004. EXPOSURES For each state, we used discrete time survival analysis to develop age trend models for RSV hospitalizations for 2 groups: moderate-preterm infants (32-34 weeks' gestational age) and term infants (37-41 weeks' gestational age). MAIN OUTCOMES AND MEASURES Age at which preterm infants' risk of RSV hospitalization equaled the risk for term infants at age 1 month. RESULTS Our cohort included 247,566 eligible infants with 5322 RSV hospitalizations. Preterm status doubled the risk for RSV hospitalization in both Florida (odds ratio = 2.41; 95% CI, 1.85-3.12) and Texas (odds ratio = 1.94; 95% CI, 1.64-2.30). Preterm infants' risk of RSV hospitalization was similar to that for 1-month-old term infants at ages 4.2 months (95% CI, 2.5-5.7) in Florida and 4.5 months (95% CI, 2.8-6.4) in Texas. CONCLUSIONS AND RELEVANCE The age at which moderate-preterm infants showed RSV hospitalization risk similar to their healthy term counterparts supports the more restrictive age thresholds in RSV immunoprophylaxis recommendations. Further studies are warranted to investigate the age-dependent risk of RSV hospitalization in other RSV risk groups.

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Heliox inhalation therapy for bronchiolitis in infants

Liet

Ducruet

Gupta

et al. 2015

Cochrane Database of Systematic Reviews

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Current evidence suggests that the addition of heliox therapy may significantly reduce a clinical score evaluating respiratory distress in the first hour after starting treatment in infants with acute RSV bronchiolitis. We noticed this beneficial effect regardless of which heliox inhalation protocol was used. Nevertheless, there was no reduction in the rate of intubation, in the rate of emergency department discharge, or in the length of treatment for respiratory distress. Heliox could reduce the length of treatment in infants requiring CPAP for severe respiratory distress. Further studies with homogeneous logistics in their heliox application are needed. Inclusion criteria must include a clinical severity score that reflects severe respiratory distress to avoid inclusion of children with mild bronchiolitis who may not benefit from heliox inhalation. Such studies would provide the necessary information as to the appropriate place for heliox in the therapeutic schedule for severe bronchiolitis.

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FLIP-2 Study

Abstract: In premature infants (32-35 WGA), only 3 independent risk factors were found to significantly increase the risk of RSV-related respiratory infection and hospitalization.

Cited by 110 publications

References 20 publications

Social, economic, and health impact of the respiratory syncytial virus: a systematic search

Social, economic, and health impact of the respiratory syncytial virus: a systematic search

Appropriateness of Age Thresholds for Respiratory Syncytial Virus Immunoprophylaxis in Moderate-Preterm Infants

Heliox inhalation therapy for bronchiolitis in infants

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