2006
DOI: 10.1074/jbc.m600466200
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Fli1 and Ets1 Have Distinct Roles in Connective Tissue Growth Factor/CCN2 Gene Regulation and Induction of the Profibrotic Gene Program

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Cited by 91 publications
(123 citation statements)
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“…Chromatin immunoprecipitation (ChIP). ChIP was performed as described previously (20). Adult dermal fibroblasts were treated with either AdGFP or AdTGF␤RI (AdALK-5) for 18 hours.…”
Section: Smad1 Signaling Pathway In Ssc 2531mentioning
confidence: 99%
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“…Chromatin immunoprecipitation (ChIP). ChIP was performed as described previously (20). Adult dermal fibroblasts were treated with either AdGFP or AdTGF␤RI (AdALK-5) for 18 hours.…”
Section: Smad1 Signaling Pathway In Ssc 2531mentioning
confidence: 99%
“…Half of the AdGFP-treated cells were also treated with TGF␤ (1 ng/ml) for 90 minutes. The cells were crosslinked and lysed, and nuclei were isolated as described previously (20). Chromatin was sheared by sonication to yield an average fragment size of 400 bp and microcentrifuged at 14,000 revolutions per minute, and supernatant containing soluble chromatin was collected.…”
Section: Smad1 Signaling Pathway In Ssc 2531mentioning
confidence: 99%
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“…9,27,28 As such, we cannot rule out the possibility that the PBE may contain more than one binding site. The various PARP-1 -binding sites differ considerably in sequence, suggesting that PARP-1 may bind to these sites as part of an enhancer/promoter binding complex containing other DNA binding factors and co-activators.…”
Section: Discussionmentioning
confidence: 99%
“…7,8 In addition, a Smad-binding element (SBE) and an Ets1-binding site are necessary for TGF-␤ induction of CCN2 in skin fibroblasts. 5,7,9 In addition, we and others also demonstrated that TGF-␤ is an important inducer of CCN2 in epithelial cells. [2][3][4][5]10 Although several consensus gene regulatory motifs, including SBE, BCE-1, Ets1, and Sp1, have been identified in the murine CCN2 promoter, their functional relevance in renal tubular epithelial cells has not yet been demonstrated; therefore, in this study, we investigated the mechanism underlying CCN2 transcription in tubular epithelial cells.…”
mentioning
confidence: 98%