FlexyDos3D: a deformable anthropomorphic 3D radiation dosimeter: radiation properties

Deene, Yves De; Skyt, P.S.; Hil, Richard; Booth, Jeremy

doi:10.1088/0031-9155/60/4/1543

Cited by 76 publications

(53 citation statements)

References 20 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The measurements summarized in this work support previous reports of dose dependence [3], dose rate dependence [5], and fractionated dose delivery [5], demonstrating the consistency of radiation dosimetric properties in individual samples of dosimeters. However the observed problem of reproducibility in the temporal measurements, not reported previously, indicates that cross calibration between and within batches will need careful attention, and readout will need to be performed soon after irradiation.…”

Section: Discussionsupporting

confidence: 88%

“…Deformable 3D radiochromic dosimeters have recently been developed that use silicone to spatially fixate dose information [2][3][4][5]. Silicone dosimeters are deformable and may be formed to any clinically relevant shape, allowing for assessment of new features, such as deformable image registration algorithms in radiation delivery planning [6].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Silicone dosimeters are deformable and may be formed to any clinically relevant shape, allowing for assessment of new features, such as deformable image registration algorithms in radiation delivery planning [6]. DeDeene et al [2,3] and Høye et al [4] have collectively identified many properties of silicone dosimeters containing leucomalachite green (LMG) as a dose indicator and chloroform as a sensitizer, such as the absorption spectra when exposed to UV light [3], dose rate dependence [2-4], effects due to fractionation of dose delivery [4], short term and long term sensitivity stability [3,4], independence of response from photon energy [2], and the effect cuvette temperature during irradiation has on the final sensitivity [3].Recently, Høye et al identified an optimal concentration of ingredients that eliminates dose rate dependence using 0.26% w/w LMG and 1% w/w chloroform, creating a dose rate independent dosimeter [5]. In this paper, the results of further investigations into these silicone radiochromic systems are reported to reproduce and confirm the results found in these previous studies, as well as further characterize the dosimetric properties of silicone dosimeters.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Characterization of a radiochromic silicone dosimeter

Carpentier

Alexander

Todd

et al. 2017

J. Phys.: Conf. Ser.

View full text Add to dashboard Cite

Abstract.A radiochromic silicone based dosimeter has been fabricated that allows for threedimensional (3D) dose verification. This paper characterizes the silicone dosimeter and verifies previous results found by other research groups. Using a recipe found to be dose rate independent, we identify the spectra of the dosimeter irradiated to different doses and verify that the response from different dose rate deliveries is constant within uncertainty. The reproducibility of a response from identically irradiated and stored cuvettes is also investigated. A noticeable difference in response indicates that there is an inhomogeneous distribution of active ingredients due to the viscous nature of the dosimeter during fabrication. Irradiating multiple cuvettes to the same dose in different fractions shows that the response decreases as the number of fractions increases. Introduction3D dosimetry has been of much interest to the radiation oncology community [1]. Deformable 3D radiochromic dosimeters have recently been developed that use silicone to spatially fixate dose information [2][3][4][5]. Silicone dosimeters are deformable and may be formed to any clinically relevant shape, allowing for assessment of new features, such as deformable image registration algorithms in radiation delivery planning [6]. DeDeene et al [2,3] and Høye et al [4] have collectively identified many properties of silicone dosimeters containing leucomalachite green (LMG) as a dose indicator and chloroform as a sensitizer, such as the absorption spectra when exposed to UV light [3], dose rate dependence [2-4], effects due to fractionation of dose delivery [4], short term and long term sensitivity stability [3,4], independence of response from photon energy [2], and the effect cuvette temperature during irradiation has on the final sensitivity [3].Recently, Høye et al. identified an optimal concentration of ingredients that eliminates dose rate dependence using 0.26% w/w LMG and 1% w/w chloroform, creating a dose rate independent dosimeter [5]. In this paper, the results of further investigations into these silicone radiochromic systems are reported to reproduce and confirm the results found in these previous studies, as well as further characterize the dosimetric properties of silicone dosimeters.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Characterization of a radiochromic silicone dosimeter

Carpentier

Alexander

Todd

et al. 2017

J. Phys.: Conf. Ser.

View full text Add to dashboard Cite

show abstract

“…The ground‐truth deformations are typically derived from either physical image/dosimeter phantoms 15 , 27 , 28 , 29 , 30 or synthetic computerized data 5 , 26 . Of note, it is unrealistic to design physical phantoms to simulate every clinical scenario.…”

Section: Discussionmentioning

confidence: 99%

Performance variations among clinically available deformable image registration tools in adaptive radiotherapy — how should we evaluate and interpret the result?

Nie

Pouliot

Smith

et al. 2016

J Applied Clin Med Phys

View full text Add to dashboard Cite

The purpose of this study is to evaluate the performance variations in commercial deformable image registration (DIR) tools for adaptive radiation therapy and further to interpret the differences using clinically available terms. Three clinical examples (prostate, head and neck (HN), and cranial spinal irradiation (CSI) with L‐spine boost) were evaluated in this study. Firstly, computerized deformed CT images were generated using simulation QA software with virtual deformations of bladder filling (prostate), neck flexion/bite‐block repositioning/tumor shrinkage (HN), and vertebral body rotation (CSI). The corresponding transformation matrices served as a “reference” for the following comparisons. Three commercialized DIR algorithms: the free‐form deformation from MIMVista 5.5 and the RegRefine from MIMMaestro 6.0, the multipass B‐spline from VelocityAI v3.0.1, and the adaptive demons from OnQ rts 2.1.15, were applied between the initial images and the deformed CT sets. The generated adaptive contours and dose distributions were compared with the “reference” and among each other. The performance in transferring contours was comparable among all three tools with an average Dice similarity coefficient of 0.81 for all the organs. However, the dose warping accuracy appeared to rely on the evaluation end points and methodologies. Point‐dose differences could show a difference of up to 23.3 Gy inside the PTVs and to overestimate up to 13.2 Gy for OARs, which was substantial for a 72 Gy prescription dose. Dosevolume histogram‐based evaluation might not be sensitive enough to illustrate all the detailed variations, while isodose assessment on a slice‐by‐slice basis could be tedious. We further explored the possibility of using 3D gamma index analysis for warping dose variation assessment, and observed differences in dose warping using different DIR tools. Overall, our results demonstrated that evaluation based only on the performance of contour transformation could not guarantee the accuracy in dose warping, while dose‐transferring validation strongly relied on the evaluation endpoint. As dose‐transferring errors could cause misinterpretations when attempting to accumulate dose for adaptive radiation therapy and more DIR tools are available for clinical use, a standard and clinically meaningful quality assurance criterion should be established for DIR QA in the near future.PACS number(s): 87.57

show abstract

Radiological tissue equivalence of deformable silicone‐based chemical radiation dosimeters (FlexyDos3D)

Wang

et al. 2019

J Applied Clin Med Phys

View full text Add to dashboard Cite

FlexyDos3D, a silicone‐based chemical radiation dosimeter, has great potential to serve as a three‐dimensional (3D) deformable dosimetric tool to verify complex dose distributions delivered by modern radiotherapy techniques. To facilitate its clinical application, its radiological tissue needs to be clarified. In this study we investigated its tissue‐equivalence in comparison with water and Solid Water (RMI457). We found that its effective and mean atomic numbers were 40% and 20% higher and the total interaction probabilities for kV x‐ray photons were larger than those of water respectively. To assess the influence of its over‐response to kV photons, its HU value was measured by kV computed tomography (CT) and was found higher than all the soft‐tissue substitutes. When applied for dose calculation without correction, this effect led to an 8% overestimation in electron density via HU‐value mapping and 0.65% underestimation in target dose. Furthermore, depth dose curves (PDDs) and off‐axis ratios (profiles) at various beam conditions as well as the dose distribution of a full‐arc VMAT plan in FlexyDos3D and reference materials were simulated by Monte Carlo, where the results showed great agreement. As indicated, FlexyDos3D exhibits excellent radiological water‐equivalence for clinical MV x‐ray dosimetry, while its nonwater‐equivalent effect for low energy x‐ray dosimetry requires necessary correction. The key findings of this study provide pertinent reference for further FlexyDos3D characterization research.

show abstract

FlexyDos3D: a deformable anthropomorphic 3D radiation dosimeter: radiation properties

Cited by 76 publications

References 20 publications

Characterization of a radiochromic silicone dosimeter

Characterization of a radiochromic silicone dosimeter

Performance variations among clinically available deformable image registration tools in adaptive radiotherapy — how should we evaluate and interpret the result?

Radiological tissue equivalence of deformable silicone‐based chemical radiation dosimeters (FlexyDos3D)

Contact Info

Product

Resources

About