Flexible Ultrathin PolyDVB/EVB Composite Membranes for the Optimization of a Whole Blood Glucose Sensor

Abstract

An ultrathin composite membrane has been developed as the outer covering barrier in a model amperometric glucose oxidase enzyme electrode. The membrane was formed by cathodic electropolymerization of divinylbenzene/ ethylvinylbenzene at the surface of a gold coated polyester support membrane. Permeability coefficients were determined for O 2 and glucose across membranes with a range of polymer thicknesses. Anionic interferents (such as ascorbate), were screened from the working electrode via a charge exclusion mechanism. The enzyme electrode showed an initial 10% signal drift when first exposed to whole human blood over a period of 2 hours, after which responses remained essentially stable. Whole blood patient glucose determinations yielded a correlation coefficient of r 2 ¼ 0.99 compared to standard hospital analyses.

Diffusion Polysiloxane Membrane to Extend the Linearity of Amperometric Glucose Sensors Integrated with Silicon Technologie

“…Diffusion membranes have included low porosity microporous membranes, silane treated, diamond-like carbon coated and lipid treated [1,2,3]. Other membranes without readily identified pores include polyamide coated cellulose, polyurethane, polypyrrol [4], cellulose acetate unmodified and surfactant treated.…”